Literature DB >> 3664082

Effect of platelet agonists on airway reactivity and intrathoracic platelet accumulation.

D N Robertson1, C P Page.   

Abstract

1 Intravenous infusion of platelet activating factor (Paf), adenosine diphosphate (ADP), collagen and the thromboxane-mimetic U46619 induced a dose-related accumulation of 111indium-labelled platelets into the thoracic region of anaesthetized guinea-pigs. 2 Intravenous infusion of Paf increased the reactivity of the airways to the spasmogen histamine. Such changes were not observed following treatment with ADP, collagen or U46619. 3 Paf-induced bronchial hyperreactivity is not secondary to pulmonary platelet recruitment, changes in basal lung function or cardiovascular changes. 4 Paf-induced bronchial hyperreactivity is not dependent upon the endogenous generation of ADP or thromboxane.

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Year:  1987        PMID： 3664082      PMCID： PMC1853636          DOI： 10.1111/j.1476-5381.1987.tb11301.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  16 in total

1.  New functions for platelets and their pathological implications.

Authors:  A Capron; J C Ameisen; M Joseph; C Auriault; A B Tonnel; J Caen
Journal:  Int Arch Allergy Appl Immunol       Date:  1985

2.  A comparison of the effects of three substance P antagonists on tachykinin-stimulated [3H]-acetylcholine release in the guinea-pig ileum.

Authors:  R L Featherstone; P Fosbraey; I K Morton
Journal:  Br J Pharmacol       Date:  1986-01       Impact factor: 8.739

3.  The platelet in asthma.

Authors:  J Morley; S Sanjar; C P Page
Journal:  Lancet       Date:  1984-11-17       Impact factor: 79.321

4.  Role of plasma exudation in asthmatic airways.

Authors:  C G Persson
Journal:  Lancet       Date:  1986-11-15       Impact factor: 79.321

5.  The effect of platelet activating factor on pulmonary beta-adrenoceptors.

Authors:  P J Barnes; B M Grandordy; C P Page; K J Rhoden; D N Robertson
Journal:  Br J Pharmacol       Date:  1987-04       Impact factor: 8.739

6.  Airway hyperresponsiveness induced by platelet-activating factor: role of thromboxane generation.

Authors:  K F Chung; H Aizawa; G D Leikauf; I F Ueki; T W Evans; J A Nadel
Journal:  J Pharmacol Exp Ther       Date:  1986-03       Impact factor: 4.030

7.  Ultrastructural evidence for extravascular platelet recruitment in the lung upon intravenous injection of platelet-activating factor (PAF-acether) to guinea-pigs.

Authors:  A Lellouch-Tubiana; J Lefort; E Pirotzky; B B Vargaftig; A Pfister
Journal:  Br J Exp Pathol       Date:  1985-06

Review 8.  The eosinophil and the pathophysiology of asthma.

Authors:  E Frigas; G J Gleich
Journal:  J Allergy Clin Immunol       Date:  1986-04       Impact factor: 10.793

9.  Inflammatory actions of platelet activating factor (Pafacether) in guinea-pig skin.

Authors:  J Morley; C P Page; W Paul
Journal:  Br J Pharmacol       Date:  1983-11       Impact factor: 8.739

10.  Effects of inhaled platelet activating factor on pulmonary function and bronchial responsiveness in man.

Authors:  F M Cuss; C M Dixon; P J Barnes
Journal:  Lancet       Date:  1986-07-26       Impact factor: 79.321
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  8 in total

1.  Effects of platelet activating factor on airway calibre, airway responsiveness, and circulating cells in asthmatic subjects.

Authors:  K F Chung; P J Barnes
Journal:  Thorax       Date:  1989-02       Impact factor: 9.139

2.  PAF-induced muscarinic cholinoceptor hyperresponsiveness of ferret tracheal smooth muscle and gland secretion in vitro.

Authors:  S E Webber; T Morikawa; J G Widdicombe
Journal:  Br J Pharmacol       Date:  1992-01       Impact factor: 8.739

3.  The involvement of platelet activating factor in endotoxin-induced pulmonary platelet recruitment in the guinea-pig.

Authors:  L Beijer; J Botting; P Crook; A O Oyekan; C P Page; R Rylander
Journal:  Br J Pharmacol       Date:  1987-12       Impact factor: 8.739

4.  Immunocytochemical localization of platelets in baboon hepatic sinusoids using monoclonal mouse anti-human platelet glycoprotein IIIa following induction of thrombocytopenia.

Authors:  J D Frank; R J Gould; L W Schaffer; J T Davidson; R E Gibson; D H Patrick; S L Vonderfecht; M E Cartwright
Journal:  Histochemistry       Date:  1992-05

5.  Effects of PAF on excitatory neuro-effector transmission in dog airways.

Authors:  K Tashiro; Z Xie; Y Ito
Journal:  Br J Pharmacol       Date:  1992-12       Impact factor: 8.739

6.  PAF-induced bronchial hyperresponsiveness in the rabbit: contribution of platelets and airway smooth muscle.

Authors:  A J Coyle; D Spina; C P Page
Journal:  Br J Pharmacol       Date:  1990-09       Impact factor: 8.739

7.  The effect of Paf antagonists on bronchial hyperresponsiveness induced by Paf, propranolol or indomethacin.

Authors:  E J Dixon; P Wilsoncroft; D N Robertson; C P Page
Journal:  Br J Pharmacol       Date:  1989-07       Impact factor: 8.739

8.  Decreased arachidonic acid metabolism in human platelets by autologous neutrophils: possible role of cell adhesion.

Authors:  B Chabannes; P Molière; Y Pacheco; M Lagarde
Journal:  Biochem J       Date:  1994-06-15       Impact factor: 3.857
  8 in total

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