Literature DB >> 3663162

Effect of adenosine and inosine on ureagenesis in hepatocytes.

R Guinzberg1, I Laguna, A Zentella, R Guzman, E Piña.   

Abstract

Adenosine and inosine produced a dose-dependent stimulation of ureagenesis in isolated rat hepatocytes. Hypoxanthine, xanthine and uric acid were without effect. Half-maximally effective concentrations were 0.08 microM for adenosine and 5 microM for inosine. Activation of ureagenesis by both nucleosides had the following characteristics: (a) it was observed with either glutamine or (NH4)2CO3, provided that glucose was present; (b) it was not detected when glucose was replaced by lactate plus oleate; (c) it was mutually antagonized by glucagon, but not by adrenaline; and (d) it was dependent on Ca2+. We suggest that the action of adenosine and inosine on ureagenesis might be of physiological significance.

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Year:  1987        PMID： 3663162      PMCID： PMC1148131          DOI： 10.1042/bj2450371

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  11 in total

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5.  Effect of adenosine on the adenine nucleotide content and metabolism of hepatocytes.

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9.  Adenosine receptor binding: structure-activity analysis generates extremely potent xanthine antagonists.

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  8 in total

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Authors:  M Gomez-Angelats; B del Santo; J Mercader; A Ferrer-Martinez; A Felipe; J Casado; M Pastor-Anglada
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  8 in total

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