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Literature DB >> 3662809

Renal handling of cadmium and cadmium-metallothionein: studies on the isolated perfused rat kidney.

Abstract

The isolated kidney perfusion model was used to study the uptake of Cd and metallothionein (MT)-complexed Cd. Cd2+ at concentrations above 40 nM strongly depressed the glomerular filtration rate (GFR), whereas MT-complexed Cd (Cd-MT) at concentrations of 0.8-920 nM had no effect on the GFR. In contrast to Cd2+, Cd-MT was readily reabsorbed by the kidney and uptake saturation for Cd-MT occurred at 240 nM. The maximal transport rate for Cd-MT calculated in this study was 18 pmoles Cd-MT . g-1 . min-1. The accumulation of Cd in the kidney was more efficient in the experiment using Cd-MT, in which case the Cd kidney contents were about 2-4 times higher than compared to CdCl2.

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Year: 1987 PMID： 3662809 DOI： 10.1007/bf00295757

Source DB: PubMed Journal: Arch Toxicol ISSN： 0340-5761 Impact factor: 5.153

38 in total

1. Measurement of cell growth in tissue culture with a phenol reagent (folin-ciocalteau).

Authors: V I OYAMA; H EAGLE
Journal: Proc Soc Exp Biol Med Date: 1956-02

2. Determination of Cd-thionein in biological materials: comparative standard recovery by five current methods using protein nitrogen for standard calibration.

Authors: H H Dieter; L Müller; J Abel; K H Summer
Journal: Toxicol Appl Pharmacol Date: 1986-09-30 Impact factor: 4.219

2. Alterations of the renal function in the isolated perfused rat kidney system after in vivo and in vitro application of S-(1,2-dichlorovinyl)-L-cysteine and S-(2,2-dichlorovinyl)-L-cysteine.

Authors: O Ilinskaja; S Vamvakas
Journal: Arch Toxicol Date: 1996 Impact factor: 5.153

3. Renal aluminum excretion.

Authors: M Wilhelm; D Höhr; J Abel; F K Ohnesorge
Journal: Biol Trace Elem Res Date: 1989 Jul-Sep Impact factor: 3.738

3 in total

Renal handling of cadmium and cadmium-metallothionein: studies on the isolated perfused rat kidney.

1. Measurement of cell growth in tissue culture with a phenol reagent (folin-ciocalteau).

2. Determination of Cd-thionein in biological materials: comparative standard recovery by five current methods using protein nitrogen for standard calibration.

3. Acute effects of cadmium on proximal tubular function in rabbits.

4. Morphologic and functional evidence for oxygen deficiency in the isolated perfused rat kidney.

5. Renal handling of polypeptide hormones (insulin, C-peptide, h-PTH) as studied in the isolated perfused rat kidney.

Review 6. Does cadmium contribute to human hypertension.

7. General aspects of cadmium: transport, uptake and metabolism by the kidney.

8. Metabolism of cadmium, zinc and copper in the rat kidney: the role of metallothionein and other binding sites.

9. Studies of cadmium uptake and metabolism by the kidney.

10. Cadmium and the kidney.

1. Comparative study on metallothionein induction in whole testicular tissue and isolated Leydig cells.

2. Alterations of the renal function in the isolated perfused rat kidney system after in vivo and in vitro application of S-(1,2-dichlorovinyl)-L-cysteine and S-(2,2-dichlorovinyl)-L-cysteine.

3. Renal aluminum excretion.