Literature DB >> 3662473

Pharmacokinetics of a single dose of rimantadine in young adults and children.

E L Anderson1, L P Van Voris, J Bartram, H E Hoffman, R B Belshe.   

Abstract

Single doses of rimantadine were given to children and young adults to evaluate the safety and pharmacokinetics of this antiviral compound. The half-life of rimantadine in young adults was 27.7 +/- 4.9 h for tablets and 27.8 +/- 8.0 h for syrup preparations. A total of 10 children, 5 to 8 years old, received a syrup preparation of rimantadine. The half-life of rimantadine in children was 24.8 +/- 9.4 h. A single dose of rimantadine was well tolerated in young adults and children.

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Year:  1987        PMID： 3662473      PMCID： PMC174886          DOI： 10.1128/AAC.31.7.1140

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  5 in total

1.  Comparative single-dose pharmacokinetics of amantadine hydrochloride and rimantadine hydrochloride in young and elderly adults.

Authors:  F G Hayden; A Minocha; D A Spyker; H E Hoffman
Journal:  Antimicrob Agents Chemother       Date:  1985-08       Impact factor: 5.191

2.  Differences in side effects of amantadine hydrochloride and rimantadine hydrochloride relate to differences in pharmacokinetics.

Authors:  F G Hayden; H E Hoffman; D A Spyker
Journal:  Antimicrob Agents Chemother       Date:  1983-03       Impact factor: 5.191

3.  Influenza in children. Relationship to other respiratory agents.

Authors:  W P Glezen; A Paredes; L H Taber
Journal:  JAMA       Date:  1980-04-04       Impact factor: 56.272

4.  Impact of type A influenza on children: a retrospective study.

Authors:  J P Mullooly; W H Barker
Journal:  Am J Public Health       Date:  1982-09       Impact factor: 9.308

5.  Comparative toxicity of amantadine hydrochloride and rimantadine hydrochloride in healthy adults.

Authors:  F G Hayden; J M Gwaltney; R L Van de Castle; K F Adams; B Giordani
Journal:  Antimicrob Agents Chemother       Date:  1981-02       Impact factor: 5.191
  5 in total
  4 in total

1.  In vitro and in vivo activities of aminoadamantane and aminoalkylcyclohexane derivatives against Trypanosoma brucei.

Authors:  J M Kelly; G Quack; M M Miles
Journal:  Antimicrob Agents Chemother       Date:  2001-05       Impact factor: 5.191

2.  The anti-influenza virus drug rimantadine has trypanocidal activity.

Authors:  J M Kelly; M A Miles; A C Skinner
Journal:  Antimicrob Agents Chemother       Date:  1999-04       Impact factor: 5.191

3.  Multiple-dose pharmacokinetics of rimantadine in elderly adults.

Authors:  R L Tominack; R J Wills; L E Gustavson; F G Hayden
Journal:  Antimicrob Agents Chemother       Date:  1988-12       Impact factor: 5.191

Review 4.  Amantadine and rimantadine prophylaxis of influenza A in nursing homes. A tolerability perspective.

Authors:  D R Guay
Journal:  Drugs Aging       Date:  1994-07       Impact factor: 3.923
  4 in total

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