| Literature DB >> 3657828 |
B E Butterworth1, J Ashby, E Bermudez, D Casciano, J Mirsalis, G Probst, G Williams.
Abstract
The in vivo rat hepatocyte DNA-repair assay is a valuable tool in assessing the genotoxic activity of chemical agents. An advantage of the system is that it reflects the complex patterns of uptake, distribution, metabolism, detoxification and excretion that actually occur in the whole animal. This article provides a typical procedure and guidelines for conducting the rat in vivo hepatocyte DNA-repair assay.Entities:
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Year: 1987 PMID： 3657828 DOI： 10.1016/0165-1218(87)90018-8
Source DB: PubMed Journal: Mutat Res ISSN： 0027-5107 Impact factor: 2.433