Literature DB >> 3655737

Cloning of aminoglycoside-resistance determinants from Streptomyces tenebrarius and comparison with related genes from other actinomycetes.

P A Skeggs1, D J Holmes, E Cundliffe.   

Abstract

At least two aminoglycoside-resistance determinants from Streptomyces tenebrarius have been cloned separately in Streptomyces lividans. In each case, resistance (to kanamycin plus apramycin or to kanamycin plus gentamicin) was expressed at the level of the ribosome and involved specific methylation of 16S ribosomal RNA. Hybridization and restriction analysis revealed that related genes were present in other aminoglycoside-producing actinomycetes.

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Year:  1987        PMID： 3655737     DOI： 10.1099/00221287-133-4-915

Source DB:  PubMed          Journal:  J Gen Microbiol        ISSN： 0022-1287


  12 in total

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2.  Molecular Biology Methods in Streptomyces rimosus, a Producer of Oxytetracycline.

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3.  Acquired gentamicin resistance by permeability impairment in Enterococcus faecalis.

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Review 4.  Comparison of Antibiotic Resistance Mechanisms in Antibiotic-Producing and Pathogenic Bacteria.

Authors:  Hiroshi Ogawara
Journal:  Molecules       Date:  2019-09-21       Impact factor: 4.411

5.  Apramycin resistance as a selective marker for gene transfer in mycobacteria.

Authors:  E Paget; J Davies
Journal:  J Bacteriol       Date:  1996-11       Impact factor: 3.490

6.  Novel plasmid-mediated 16S rRNA m1A1408 methyltransferase, NpmA, found in a clinically isolated Escherichia coli strain resistant to structurally diverse aminoglycosides.

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Journal:  Antimicrob Agents Chemother       Date:  2007-09-17       Impact factor: 5.191

7.  Analysis of a ribosomal RNA methylase gene from Streptomyces tenebrarius which confers resistance to gentamicin.

Authors:  D J Holmes; E Cundliffe
Journal:  Mol Gen Genet       Date:  1991-10

8.  Plasmid-mediated high-level resistance to aminoglycosides in Enterobacteriaceae due to 16S rRNA methylation.

Authors:  Marc Galimand; Patrice Courvalin; Thierry Lambert
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9.  Aminoglycoside resistance genes sgm and kgmB protect bacterial but not yeast small ribosomal subunits in vitro despite high conservation of the rRNA A-site.

Authors:  Tatjana Ilic Tomic; Ivana Moric; Graeme L Conn; Branka Vasiljevic
Journal:  Res Microbiol       Date:  2008-10-01       Impact factor: 3.992

10.  Determination of the target nucleosides for members of two families of 16S rRNA methyltransferases that confer resistance to partially overlapping groups of aminoglycoside antibiotics.

Authors:  Miloje Savic; Josip Lovric; Tatjana Ilic Tomic; Branka Vasiljevic; Graeme L Conn
Journal:  Nucleic Acids Res       Date:  2009-07-09       Impact factor: 16.971
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