Literature DB >> 3654886

Determination of metoprolol and two major metabolites in plasma and urine by column liquid chromatography and fluorometric detection.

K Balmér1, Y Y Zhang, P O Lagerström, B A Persson.   

Abstract

Metoprolol and its alpha-hydroxy metabolite were determined in plasma down to 2 nmol/l (S.D. 10-15%) after solvent extraction and bonded-phase liquid chromatography with fluorometric detection. The major metabolite with a carboxylic function was also measured in plasma when liquid-solid extraction on a column activated with dodecyl sulphate was applied. In urine the three components were assayed by direct injection of a diluted sample.

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Year:  1987        PMID： 3654886     DOI： 10.1016/0378-4347(87)80129-9

Source DB:  PubMed          Journal:  J Chromatogr


  3 in total

1.  Reduced sensitivity to beta-adrenoceptor stimulation and blockade in insulin dependent diabetic patients with hypoglycaemia unawareness.

Authors:  T S Trovik; R Jaeger; R Jorde; G Sager
Journal:  Br J Clin Pharmacol       Date:  1994-11       Impact factor: 4.335

2.  Steady-state bioavailability and day-to-day variability of a multiple-unit (CR/ZOK) and a single-unit (OROS) delivery system of metoprolol after once-daily dosing.

Authors:  A Sandberg; B Abrahamsson; A Svenheden; B Olofsson; R Bergstrand
Journal:  Pharm Res       Date:  1993-01       Impact factor: 4.200

3.  Influence of CYP2D6-dependent metabolism on the steady-state pharmacokinetics and pharmacodynamics of metoprolol and nicardipine, alone and in combination.

Authors:  M A Laurent-Kenesi; C Funck-Brentano; J M Poirier; D Decolin; P Jaillon
Journal:  Br J Clin Pharmacol       Date:  1993-12       Impact factor: 4.335
  3 in total

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