| Literature DB >> 3653415 |
Abstract
Mifepristone, (RU 486, Roussel Uclaf, Romainville, France), a progesterone (P) receptor blocking agent, and Epostane, (WIN 32,729, Sterling-Winthrop, Guildford, United Kingdom), a P synthesis inhibitor, were compared for their ability to terminate early human pregnancy. Seventy-eight healthy women, with a gestational length of less than 49 days from the last menstrual period and who requested termination of pregnancy, were recruited to the study. The patients were randomly allocated to three treatment regimens: (1) Mifepristone 25 mg bid for 7 days; (2) Mifepristone 50 mg bid for 7 days; and (3) Epostane 200 mg qid for 7 days. The results of the study confirmed that both compounds are potent abortifacients in early human pregnancy. No difference in efficacy was seen between the two dose regimens of Mifepristone, which both resulted in 61% complete abortions. Seventy-three percent aborted completely in the Epostane group. Subjective side effects, especially nausea, were more common in the women treated with Epostane, but no serious side effects were seen.Entities:
Keywords: Abortifacient Agents; Abortion, Drug Induced; Abortion, Induced; Biology; Contraception; Contraception Research; Developed Countries; Diseases; Endocrine System; Enzyme Inhibitors; Enzymes And Enzyme Inhibitors; Europe; Family Planning; Female Contraception; Fertility Control, Postconception; Hormone Antagonists--administraction and dosage; Hormone Receptors; Hormones; Membrane Proteins; Nausea; Northern Europe; Physiology; Pregnancy; Pregnancy, First Trimester; Reproduction; Reproductive Control Agents; Scandinavia; Self Care; Signs And Symptoms; Steroid Abortifacients--administraction and dosage; Sweden; Treatment
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Year: 1987 PMID： 3653415 DOI： 10.1016/s0015-0282(16)59465-5
Source DB: PubMed Journal: Fertil Steril ISSN： 0015-0282 Impact factor: 7.329