Literature DB >> 3653341

Separation of canavanine and canaline by high performance liquid chromatography.

J N van Balgooy1.   

Abstract

The plant amino acid canavanine and its hydrolytic product canaline were successfully separated and identified by Reverse Phase High Performance Liquid Chromatograph (RP-HPLC). This procedure was used to demonstrate the arginase-mediated cleavage of canavanine to yield canaline and urea, and the subsequent formation of a Schiff's base complex between canaline and pyridoxal phosphate. Both aforementioned reactions were demonstrated by RP-HPLC.

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Year:  1987        PMID： 3653341     DOI： 10.1007/BF01952232

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  16 in total

Review 1.  The biological and biochemical properties of L-canaline, a naturally occurring structural analogue of L-ornithine.

Authors:  G A Rosenthal
Journal:  Life Sci       Date:  1978-07-10       Impact factor: 5.037

2.  Inhibition of pyridoxal enzymes by L-canaline.

Authors:  E L Rahiala; M Kekomäki; J Jänne; A Raina; N C Räihä
Journal:  Biochim Biophys Acta       Date:  1971-02-10

3.  Mechanism of canavanine death in Escherichia coli. I. Effect of canvainine on macromolecular synthesis.

Authors:  C F Schachtele; P Rogers
Journal:  J Mol Biol       Date:  1968-05-14       Impact factor: 5.469

4.  Preparation and colorimetric analysis of L-canavanine.

Authors:  G A Rosenthal
Journal:  Anal Biochem       Date:  1977-01       Impact factor: 3.365

5.  Antitumor activity of L-canavanine against L1210 murine leukemia.

Authors:  M H Green; T L Brooks; J Mendelsohn; S B Howell
Journal:  Cancer Res       Date:  1980-03       Impact factor: 12.701

6.  Mode of inhibition of ornithine aminotransferase by L-canaline.

Authors:  K Kito; Y Sanada; N Katunuma
Journal:  J Biochem       Date:  1978-01       Impact factor: 3.387

7.  Enhancement of human tumor cell killing by L-canavanine in combination with gamma-radiation.

Authors:  M H Green; J F Ward
Journal:  Cancer Res       Date:  1983-09       Impact factor: 12.701

8.  Radiochemical synthesis of DL-canaline and the colorimetric assay of canaline.

Authors:  G A Rosenthal; D Thomas
Journal:  Anal Biochem       Date:  1984-07       Impact factor: 3.365

9.  Effects of L-canavanine on immune function in normal and autoimmune mice: disordered B-cell function by a dietary amino acid in the immunoregulation of autoimmune disease.

Authors:  P E Prete
Journal:  Can J Physiol Pharmacol       Date:  1985-07       Impact factor: 2.273

10.  L-Canavanine and protein synthesis in the tobacco hornworm Manduca sexta.

Authors:  G A Rosenthal; D L Dahlman
Journal:  Proc Natl Acad Sci U S A       Date:  1986-01       Impact factor: 11.205
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