| Literature DB >> 3653238 |
J Yamada1, H Wakita, Y Sugimoto, K Horisaka.
Abstract
The effect on the body temperature of mice of tryptamine administered by intracerebroventricular (i.c.v.) injection was studied. Tryptamine given i.c.v. produced a significant hypothermia above a dosage of 5 nmol. The hypothermic effect of tryptamine was inhibited by methysergide whereas ketanserin and p-chlorophenylalanine did not affect it. These data demonstrate that the hypothermia induced by tryptamine i.c.v. is produced by direct activation of the 5-HT1 receptor.Entities:
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Year: 1987 PMID： 3653238 DOI： 10.1016/0014-2999(87)90505-x
Source DB: PubMed Journal: Eur J Pharmacol ISSN： 0014-2999 Impact factor: 4.432