Literature DB >> 3653224

7-Ethoxyresorufin deethylase (EROD) in human liver--the effect of alcoholic liver disease.

K W Woodhouse1, E Mutch, F M Williams, O F James, M D Rawlins.   

Abstract

We have investigated the effect of alcoholic liver disease (ALD) on the metabolism of 7-ethoxycoumarin 0-deethylase in human liver microsomes. EROD activity was significantly reduced in tissue from ALD patients who smoked, compared to smoking controls. A similar trend was seen in non-smokers. These results have implications for the metabolism of environmental carcinogens.

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Year:  1987        PMID： 3653224     DOI： 10.1007/BF02455988

Source DB:  PubMed          Journal:  Eur J Clin Pharmacol        ISSN： 0031-6970            Impact factor:   2.953


  8 in total

1.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

2.  Hepatocellular carcinoma in Great Britain: influence of age, sex, HBsAg status, and aetiology of underlying cirrhosis.

Authors:  P J Johnson; N Krasner; B Portmann; A L Eddleston; R Williams
Journal:  Gut       Date:  1978-11       Impact factor: 23.059

Review 3.  The metabolic activation of chemical carcinogens.

Authors:  P Sims
Journal:  Br Med Bull       Date:  1980-01       Impact factor: 4.291

4.  Ethoxyresorufin O-deethylation by human liver microsomes.

Authors:  F M Williams; E Mutch; K W Woodhouse; D Lambert; M D Rawlins
Journal:  Br J Clin Pharmacol       Date:  1986-09       Impact factor: 4.335

5.  Differential effects of phenobarbitone and 3-methylcholanthrene induction on the hepatic microsomal metabolism and cytochrome P-450-binding of phenoxazone and a homologous series of its n-alkyl ethers (alkoxyresorufins).

Authors:  M D Burke; R T Mayer
Journal:  Chem Biol Interact       Date:  1983-07-15       Impact factor: 5.192

6.  The effect of alcoholic cirrhosis on the activities of microsomal aldrin epoxidase, 7-ethoxycoumarin O-de-ethylase and epoxide hydrolase, and on the concentrations of reduced glutathione in human liver.

Authors:  K W Woodhouse; F M Williams; E Mutch; P Wright; O F James; M D Rawlins
Journal:  Br J Clin Pharmacol       Date:  1983-06       Impact factor: 4.335

7.  The effect of alcoholic cirrhosis on the two kinetic components (high and low affinity) of the microsomal 0-deethylation of 7-ethoxycoumarin in human liver.

Authors:  K W Woodhouse; F M Williams; E Mutch; P Wright; O F James; M D Rawlins
Journal:  Eur J Clin Pharmacol       Date:  1984       Impact factor: 2.953

8.  Influence of liver disease and environmental factors on hepatic monooxygenase activity in vitro.

Authors:  M J Brodie; A R Boobis; C J Bulpitt; D S Davies
Journal:  Eur J Clin Pharmacol       Date:  1981       Impact factor: 2.953
  8 in total
  1 in total

1.  Conjugation pathways in liver disease.

Authors:  G M Pacifici; A Viani; M Franchi; S Santerini; A Temellini; L Giuliani; M Carrai
Journal:  Br J Clin Pharmacol       Date:  1990-09       Impact factor: 4.335
  1 in total

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