Literature DB >> 3645271

The significance of proto-oncogenes in carcinogenesis.

P Rosen.   

Abstract

A survey of the literature on activated proto-oncogenes shows that they are involved in the development of cancer but apparently not in the initiation process. The review of Klein and Klein comes to conclusions in opposition to the review of Duesberg. I favor the latter here. Active proto-oncogenes may be part of the developmental process of carcinogenesis but are not initiators of carcinogenesis.

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Year:  1987        PMID: 3645271     DOI: 10.1016/0306-9877(87)90004-1

Source DB:  PubMed          Journal:  Med Hypotheses        ISSN: 0306-9877            Impact factor:   1.538


  1 in total

1.  Transforming function of proto-ras genes depends on heterologous promoters and is enhanced by specific point mutations.

Authors:  A K Chakraborty; K Cichutek; P H Duesberg
Journal:  Proc Natl Acad Sci U S A       Date:  1991-03-15       Impact factor: 11.205

  1 in total

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