| Literature DB >> 3640831 |
E F Meyer, R Radhakrishnan, G M Cole, L G Presta.
Abstract
A single crystal of porcine pancreatic elastase was mounted in a thin-walled capillary and allowed to react with acetyl-Ala-Pro-Ala-paranitroanalide. Diffraction data to 1.65 A resolution were measured and the isomorphous structure was solved from the difference Fourier map. The structure contains two surprises. Two molecules of the product: acetyl-Ala-Pro-Ala molecule are bound in the extended binding site. Both molecules are bound backwards with respect to the established mode of peptide binding.Entities:
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Year: 1986 PMID： 3640831 DOI： 10.1016/0022-2836(86)90322-0
Source DB: PubMed Journal: J Mol Biol ISSN： 0022-2836 Impact factor: 5.469