| Literature DB >> 3639739 |
J Sri-Widada, H Graafland, R Dietz, C Brunel, G Cathala, P Jeanteur.
Abstract
Analysis of sera from 168 patients with autoimmune disorders revealed that one patient with Sjôgren's syndrome produced antibodies against deproteinized initiator methionine tRNA in addition to those against La protein. This anti-tRNAimet recognizes also tRNAimet from yeast but not from Phaseolus vulgaris chloroplasts (bean) or E. coli. It appears therefore that the epitope could be located in the TF loop in which an A residue in position 60 and the AUCG sequence are the only common features in yeast and human tRNAimet.Entities:
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Year: 1986 PMID： 3639739 DOI： 10.1016/s0006-291x(86)80109-7
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575