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Literature DB >> 363954

A rapid objective method for measuring the yeast opsonisation activity of serum.

Abstract

A simple, objective semi-quantitative assay for yeast opsonisation by normal polymorphs has been developed. This depends on electronically counting the number of free unphagocytosed yeast particles on a Coulter counter. The method has been compared with the widely used microscope technique and shows excellent correlation. The sera of 112 unselected school-children gave a distribution curve consistent with 2 peaks; 7 gave values less than 2 S.D.s below the mean confirming the high incidence of this immunodeficiency.

Entities: Disease Species

Mesh：

Substances：
Opsonin Proteins

Year: 1978 PMID： 363954 DOI： 10.1016/0022-1759(78)90129-1

Source DB: PubMed Journal: J Immunol Methods ISSN： 0022-1759 Impact factor: 2.303

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Cited

21 in total

1. Deficiency of mannan binding protein--a new complement deficiency syndrome.

Authors: M W Turner
Journal: Clin Exp Immunol Date: 1991-10 Impact factor: 4.330

2. The level of mannan-binding protein regulates the binding of complement-derived opsonins to mannan and zymosan at low serum concentrations.

Authors: M Super; R J Levinsky; M W Turner
Journal: Clin Exp Immunol Date: 1990-02 Impact factor: 4.330

3. Suboptimal C3b/C3bi deposition and defective yeast opsonization. I. Evidence for the absence of essential co-factor activity.

Authors: M W Turner; N D Seymour; M D Kazatchkine; J F Mowbray
Journal: Clin Exp Immunol Date: 1985-11 Impact factor: 4.330

4. Suboptimal C3b/C3bi deposition and defective yeast opsonization. II. Partial purification and preliminary characterization of an opsonic co-factor able to correct sera with the defect.

Authors: M W Turner; N D Seymour; M D Kazatchkine; J F Mowbray
Journal: Clin Exp Immunol Date: 1985-11 Impact factor: 4.330

5. Evaluation of C3b/C3bi opsonization and chemiluminescence with selected yeasts and bacteria using sera of different opsonic potential.

Authors: M W Turner; C Grant; N D Seymour; B Harvey; R J Levinsky
Journal: Immunology Date: 1986-05 Impact factor: 7.397

A rapid objective method for measuring the yeast opsonisation activity of serum.

1. Deficiency of mannan binding protein--a new complement deficiency syndrome.

2. The level of mannan-binding protein regulates the binding of complement-derived opsonins to mannan and zymosan at low serum concentrations.

3. Suboptimal C3b/C3bi deposition and defective yeast opsonization. I. Evidence for the absence of essential co-factor activity.

4. Suboptimal C3b/C3bi deposition and defective yeast opsonization. II. Partial purification and preliminary characterization of an opsonic co-factor able to correct sera with the defect.

5. Evaluation of C3b/C3bi opsonization and chemiluminescence with selected yeasts and bacteria using sera of different opsonic potential.

6. Defective yeast opsonisation of serum in tuberculosis.

7. Polymorphonuclear neutrophil iodination response as an estimate of defective yeast opsonization.

8. Yeast opsonization in newborn infants and its relationship to parental atopy.

9. Defective yeast opsonisation and functional deficiency of complement in sickle cell disease.

10. A common congenital immunodeficiency predisposing to infection and atopy in infancy.