Literature DB >> 363605

'In vitro' study of a reaction between the complement system and cellular DNA.

A P Peltier, L Cyna, A Dryll.   

Abstract

A direct reaction between the complement system and DNA in nuclei was demonstrated in vitro by an indirect immunofluorescence technique using cryostat-cut sections of rat liver as a substrate. This reaction occurred at physiological conditions of pH and molarity and was abolished by pre-treatment of the tissue sections by DNase. It begins by the fixation of C1q and involves the fixation and probably the activation of apparently all the components of the classical pathway of the complement system. The pattern of fluorescence given by this reaction was similar to the pattern given by anti-DNA antibodies present in sera from systemic lupus erythematosus (SLE) patients.

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Year:  1978        PMID： 363605      PMCID： PMC1457527     

Source DB:  PubMed          Journal:  Immunology        ISSN： 0019-2805            Impact factor:   7.397


  15 in total

1.  BIOLOGIC PROPERTIES OF POLYNUCLEOTIDES. VI. FURTHER STUDIES ON THE MECHANISM OF COMPLEMENT INHIBITION BY POLYINOSINIC ACID: THE INACTIVATION OF THE FOURTH COMPONENT OF COMPLEMENT.

Authors:  S YACHNIN; D ROSENBLUM; D CHATMAN
Journal:  J Immunol       Date:  1964-10       Impact factor: 5.422

2.  Mode of interaction of different polyanions with the first (C1, C1), the second (C2) and the fourth (C4) component of complement--I. Effect on fluid phase C1 and on C1 bound to EA or to EAC4.

Authors:  E Raepple; H U Hill; M Loos
Journal:  Immunochemistry       Date:  1976-03

3.  C2 deficiency, platelet aggregation reduction and Lobstein's disease in the same family.

Authors:  G Tobelem; J L Wautier; A P Peltier
Journal:  Biomedicine       Date:  1974-04-10

4.  [Antinuclear antibodies revealed by immunofluorescence and other immunologic methods].

Authors:  A Cannat; M Seligmann
Journal:  Sem Hop       Date:  1965-04-14

5.  [Determination of the immunoglobulin type of complement fixing and non-fixing anti-nuclear factors].

Authors:  A P Peltier; G Strejcek
Journal:  Rev Fr Etud Clin Biol       Date:  1969-10

6.  Ribonucleoprotein (RNP) soluble nuclear antigen: demonstration of its reaction with serum antibodies by counter-immunoelectrophoresis and further partial characterization.

Authors:  A P Peltier; C Aussel; T Haim; L Cyna
Journal:  J Immunol Methods       Date:  1977       Impact factor: 2.303

7.  Precipitin reactions of the C1q component of complement with aggregated gamma-globulin and immune complexes in gel diffusion.

Authors:  V Agnello; R J Winchester; H G Kunkel
Journal:  Immunology       Date:  1970-12       Impact factor: 7.397

8.  Interaction of C-reactive protein complexes with the complement system. I. Consumption of human complement associated with the reaction of C-reactive protein with pneumococcal C-polysaccharide and with the choline phosphatides, lecithin and sphingomyelin.

Authors:  M H Kaplan; J E Volanakis
Journal:  J Immunol       Date:  1974-06       Impact factor: 5.422

9.  Precipitin reactions between polyribonucleotides and heat labile serum factors.

Authors:  P G Natali; E M Tan
Journal:  J Immunol       Date:  1972-02       Impact factor: 5.422

10.  Complement activation by interaction of polyanions and polycations. III. Complement activation by interaction of multiple polyanious and polycations is the presence of C-reactive protein.

Authors:  D R Claus; J Siegel; K Petras; D Skor; A P Osmand; H Gewurz
Journal:  J Immunol       Date:  1977-01       Impact factor: 5.422
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  5 in total

1.  Characterisation of non-histone nuclear proteins cross reactive with purified rheumatoid factors.

Authors:  J C Mason; P J Venables; P R Smith; R N Maini
Journal:  Ann Rheum Dis       Date:  1985-05       Impact factor: 19.103

2.  Factors affecting complement activation by Staphylococcus aureus cell walls, their components, and mutants altered in teichoic acid.

Authors:  B J Wilkinson; Y Kim; P K Peterson
Journal:  Infect Immun       Date:  1981-04       Impact factor: 3.441

3.  Localization of sites through which C-reactive protein binds and activates complement to residues 14-26 and 76-92 of the human C1q A chain.

Authors:  H Jiang; F A Robey; H Gewurz
Journal:  J Exp Med       Date:  1992-05-01       Impact factor: 14.307

4.  The endothelial deprotection hypothesis for lupus pathogenesis: the dual role of C1q as a mediator of clearance and regulator of endothelial permeability.

Authors:  József Prechl; László Czirják
Journal:  F1000Res       Date:  2015-01-26

5.  Antibody-independent complement activation by myelin via the classical complement pathway.

Authors:  J C Cyong; S S Witkin; B Rieger; E Barbarese; R A Good; N K Day
Journal:  J Exp Med       Date:  1982-02-01       Impact factor: 14.307
  5 in total

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