Literature DB >> 3632694

Increased 13-hydroxyoctadecadienoic acid content in lipopolysaccharide stimulated macrophages.

U F Schade, I Burmeister, R Engel.   

Abstract

Endotoxin-stimulated mouse peritoneal macrophages were found to contain 13-hydroxyoctadecadienoic acid, which was released upon alkaline hydrolysis of the cells. Compared to untreated cells, incubation with LPS increased the content of 13-hydroxyoctadecadienoic acid in macrophage hydrolysates to about 8-fold. Analysis of the material on chiralphase HPLC revealed that it consisted prevalently of 13(S)-hydroxyoctadecadienoic acid. This indicates its enzymatic origine.

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Year:  1987        PMID： 3632694     DOI： 10.1016/0006-291x(87)90986-7

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  5 in total

Review 1.  Mononuclear phagocytes and eicosanoids: aspects of their synthesis and biological activities.

Authors:  U F Schade; I Burmeister; E Elekes; R Engel; D T Wolter
Journal:  Blut       Date:  1989-12

2.  Pro-oxidant effects of lipoxygenase-derived peroxides on the copper-initiated oxidation of low-density lipoprotein.

Authors:  V J O'Leary; V M Darley-Usmar; L J Russell; D Stone
Journal:  Biochem J       Date:  1992-03-15       Impact factor: 3.857

3.  Tumour necrosis factor production in a rat airpouch model of inflammation: role of eicosanoids.

Authors:  M L Ferrándiz; S J Foster
Journal:  Agents Actions       Date:  1991-03

4.  Lipoxygenase metabolites of arachidonic and linoleic acids modulate the adhesion of tumor cells to endothelium via regulation of protein kinase C.

Authors:  B Liu; J Timar; J Howlett; C A Diglio; K V Honn
Journal:  Cell Regul       Date:  1991-12

5.  CD34(+) hematopoietic stem cells exert accessory function in lipopolysaccharide-induced T cell stimulation and CD80 expression on monocytes.

Authors:  T Mattern; G Girroleit; H D Flad; E T Rietschel; A J Ulmer
Journal:  J Exp Med       Date:  1999-02-15       Impact factor: 14.307
  5 in total

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