Literature DB >> 3631701

In vitro platelet release by rat megakaryocytes: effect of metabolic inhibitors and cytoskeletal disrupting agents.

P J Handagama, B F Feldman, N C Jain, T B Farver, C S Kono.   

Abstract

Development of an in vitro visual assay facilitated the study of large numbers of megakaryocytes undergoing proplatelet formation in short-term cultures. Approximately 9% of megakaryocytes formed platelets during a 24-hour period. In the presence of an inhibitor of anaerobic glycolysis (NaF), proplatelet formation was inhibited, whereas inhibitors of respiration (NaCN) did not significantly (P greater than 0.05) decrease proplatelet formation. Presence of the microtubule-disrupting agents colchicine and vincristine sulfate in culture medium inhibited proplatelet formation, whereas the microfilament-disrupting agent cytochalasin B had a less pronounced inhibition.

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Year:  1987        PMID： 3631701

Source DB:  PubMed          Journal:  Am J Vet Res        ISSN： 0002-9645            Impact factor:   1.156


  11 in total

1.  Differential roles of microtubule assembly and sliding in proplatelet formation by megakaryocytes.

Authors:  Sunita R Patel; Jennifer L Richardson; Harald Schulze; Eden Kahle; Niels Galjart; Ksenija Drabek; Ramesh A Shivdasani; John H Hartwig; Joseph E Italiano
Journal:  Blood       Date:  2005-08-23       Impact factor: 22.113

Review 2.  In vivo platelet production from mature megakaryocytes: does platelet release occur via proplatelets?

Authors:  Goro Kosaki
Journal:  Int J Hematol       Date:  2005-04       Impact factor: 2.490

Review 3.  The biogenesis of platelets from megakaryocyte proplatelets.

Authors:  Sunita R Patel; John H Hartwig; Joseph E Italiano
Journal:  J Clin Invest       Date:  2005-12       Impact factor: 14.808

Review 4.  New insights into cytoskeletal remodeling during platelet production.

Authors:  Dorsaf Ghalloussi; Ankita Dhenge; Wolfgang Bergmeier
Journal:  J Thromb Haemost       Date:  2019-07-16       Impact factor: 5.824

5.  Megakaryocyte-derived microparticles: direct visualization and distinction from platelet-derived microparticles.

Authors:  Robert Flaumenhaft; James R Dilks; Jennifer Richardson; Eva Alden; Sunita R Patel-Hett; Elisabeth Battinelli; Giannoula L Klement; Martha Sola-Visner; Joseph E Italiano
Journal:  Blood       Date:  2008-09-18       Impact factor: 22.113

6.  Microtubule sliding drives proplatelet elongation and is dependent on cytoplasmic dynein.

Authors:  Markus Bender; Jonathan N Thon; Allen J Ehrlicher; Stephen Wu; Linas Mazutis; Emoke Deschmann; Martha Sola-Visner; Joseph E Italiano; John H Hartwig
Journal:  Blood       Date:  2014-11-19       Impact factor: 22.113

7.  Synthesis and dephosphorylation of MARCKS in the late stages of megakaryocyte maturation drive proplatelet formation.

Authors:  Kellie R Machlus; Stephen K Wu; Deborah J Stumpo; Thomas S Soussou; David S Paul; Robert A Campbell; Hermann Kalwa; Thomas Michel; Wolfgang Bergmeier; Andrew S Weyrich; Perry J Blackshear; John H Hartwig; Joseph E Italiano
Journal:  Blood       Date:  2016-01-07       Impact factor: 22.113

8.  Effects of vinblastine on neuropeptide Y levels in the sympathoadrenal system, bone marrow and thrombocytes of the rat.

Authors:  A Hemsén; J Pernow; B I Millberg; J M Lundberg
Journal:  Agents Actions       Date:  1991-11

9.  Blood platelets are assembled principally at the ends of proplatelet processes produced by differentiated megakaryocytes.

Authors:  J E Italiano; P Lecine; R A Shivdasani; J H Hartwig
Journal:  J Cell Biol       Date:  1999-12-13       Impact factor: 10.539

10.  Differential regulation of the apoptotic machinery during megakaryocyte differentiation and platelet production by inhibitor of apoptosis protein Livin.

Authors:  I Abd-Elrahman; V Deutsch; M Pick; S Kay; T Neuman; R Perlman; D Ben-Yehuda
Journal:  Cell Death Dis       Date:  2013-11-28       Impact factor: 8.469
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