| Literature DB >> 3630638 |
Abstract
The mortality of cerebrovascular diseases in Denmark was analysed for men and women 15-44 years of age, in a 14-year period before and after the appearance of oral contraceptives (OC) in 1966. 1,670 deaths were registered over 28 years, during which the female incidence of cerebrovascular deaths increased by 19% (P less than 0.025), while the male mortality was unchanged. Women showed a percentage increase in deaths from cerebral thromboembolic attacks (CTA) of 33%, men a fall of 14%. The increase of female CTA deaths was most pronounced in the young fertile group, the age group with a high OC use. A relative risk of CTA of 3.3-4.5 for OC users compared with non-users could explain the CTA trend difference between women and men. No other single risk factor responsible for the observed trends could be identified. Both women and men had a significant increase in the mortality of subarachnoidal hemorrhages, and a significant fall in the mortality of intracerebral hemorrhages.Entities:
Keywords: Biology; Cardiovascular Effects; Cerebrovascular Effects--changes; Cerebrovascular Effects--men; Cerebrovascular Effects--women; Contraception; Contraceptive Agents; Contraceptive Agents, Female; Contraceptive Methods--side effects; Correlation Studies; Demographic Factors; Denmark; Developed Countries; Diseases; Embolism; Epidemiologic Methods; Europe; Family Planning; Mortality Determinants; Mortality--changes; Northern Europe; Oral Contraceptives--side effects; Physiology; Population; Population Characteristics; Population Dynamics; Research Methodology; Scandinavia; Sex Factors; Statistical Studies; Studies; Thromboembolism--women; Vascular Diseases
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Year: 1987 PMID： 3630638 DOI： 10.1111/j.1600-0404.1987.tb05473.x
Source DB: PubMed Journal: Acta Neurol Scand ISSN： 0001-6314 Impact factor: 3.209