Depression in the menopause.

Epidemiologic studies have demonstrated an increase in complaints of depressed mood and other minor psychological changes from patients in the perimenopause. The etiology of these complaints has been the subject of much controversy. Current evidence supports a biopsychosocial etiological model. Underlying endocrinologic changes trigger emotional complaints in women who are vulnerable by virtue of developmental factors, personality, psychiatric history, known vulnerability to hormonally triggered mood changes, or current social problems.