Literature DB >> 3627358

Stimulation of phospholipase D activity and indication of acetylcholine synthesis by oleate in rat brain synaptosomal preparations.

H Hattori, J N Kanfer, R Massarelli.   

Abstract

It had been previously demonstrated that the oleate activation of synaptosomal membrane phospholipase D liberated choline which was available for acetylcholine formation. The present investigations were undertaken to determine if oleate might have an effect on choline uptake by synaptosomes. It was observed that oleate interfered with choline uptake when incubations were carried out at 37 degrees C but uptake was stimulated at 3 degrees C. Oleate was the most effective fatty acid of several tested. Preliminary observations suggest the presence of a membranous form of choline acetyltransferase.

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Year:  1987        PMID： 3627358     DOI： 10.1007/BF00970523

Source DB:  PubMed          Journal:  Neurochem Res        ISSN： 0364-3190            Impact factor:   3.996


  14 in total

1.  The isolation of nerve endings from brain: an electron-microscopic study of cell fragments derived by homogenization and centrifugation.

Authors:  E G GRAY; V P WHITTAKER
Journal:  J Anat       Date:  1962-01       Impact factor: 2.610

2.  Choline acetyltransferase binding to and release from membranes.

Authors:  F Fonnum
Journal:  Biochem J       Date:  1968-09       Impact factor: 3.857

Review 3.  Problems in the organization and control of acetylcholine synthesis in brain neurons.

Authors:  S Tucek
Journal:  Prog Biophys Mol Biol       Date:  1984       Impact factor: 3.667

4.  Two nonspecific phospholipid exchange proteins from beef liver. I. Purification and characterization.

Authors:  R C Crain; D B Zilversmit
Journal:  Biochemistry       Date:  1980-04-01       Impact factor: 3.162

5.  Influx, metabolism and efflux of choline in nerve cells and synaptosomes: role of sialocompounds and glycoconjugates.

Authors:  R Massarelli; A Gorio; H Dreyfus
Journal:  J Physiol (Paris)       Date:  1982

6.  Synaptosomal phospholipase D potential role in providing choline for acetylcholine synthesis.

Authors:  H Hattori; J N Kanfer
Journal:  J Neurochem       Date:  1985-11       Impact factor: 5.372

7.  Synaptosomal phospholipase D: potential role in providing choline for acetylcholine synthesis.

Authors:  H Hattori; J N Kanfer
Journal:  Biochem Biophys Res Commun       Date:  1984-11-14       Impact factor: 3.575

Review 8.  The base exchange enzymes and phospholipase D of mammalian tissue.

Authors:  J N Kanfer
Journal:  Can J Biochem       Date:  1980-12

9.  Choline biosynthesis by a preparation enriched in synaptosomes from rat brain.

Authors:  J K Blusztajn; R J Wurtman
Journal:  Nature       Date:  1981-04-02       Impact factor: 49.962

10.  Permeability of microsomal membranes isolated from rat liver.

Authors:  R Nilsson; E Peterson; G Dallner
Journal:  J Cell Biol       Date:  1973-03       Impact factor: 10.539
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  2 in total

1.  Phospholipase D-catalyzed hydrolysis of phosphatidylcholine provides the choline precursor for acetylcholine synthesis in a human neuronal cell line.

Authors:  H C Lee; M P Fellenz-Maloney; M Liscovitch; J K Blusztajn
Journal:  Proc Natl Acad Sci U S A       Date:  1993-11-01       Impact factor: 11.205

2.  Characterization of phospholipase D activity in bovine photoreceptor membranes.

Authors:  G A Salvador; N M Giusto
Journal:  Lipids       Date:  1998-09       Impact factor: 1.880
  2 in total

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