Literature DB >> 36272025

Assessing real-world effectiveness of therapies: what is the impact of incretin-based treatments on hospital use for patients with type 2 diabetes?

Clémence Bussiere1,2, Pauline Chauvin3,4, Jean-Michel Josselin5, Christine Sevilla-Dedieu6.   

Abstract

BACKGROUND: Managing type 2 diabetes represents a major public health concern due to its important and increasing prevalence. Our study investigates the impact of taking incretin-based medication on the risk of being hospitalized and the length of hospital stay for individuals with type 2 diabetes.
METHOD: We use claim panel data from 2011 to 2015 and provide difference-in-differences (DID) estimations combined with matching techniques to better ensure the treatment and control groups' comparability. Our propensity score selects individuals according to their probability of taking an incretin-based treatment in 2013 (N = 2,116). The treatment group includes individuals benefiting from incretin-based treatments from 2013 to 2015 and is compared to individuals not benefiting from such a treatment but having a similar probability of taking it.
RESULTS: After controlling for health-related and socio-economic variables, we show that benefiting from an incretin-based treatment does not significantly impact the probability of being hospitalized but does significantly decrease the annual number of days spent in the hospital by a factor rate of 0.621 compared with the length of hospital stays for patients not benefiting from such a treatment.
CONCLUSION: These findings highlight the potential implications for our health care system in case of widespread use of these drugs among patients with severe diabetes.
© 2022. The Author(s).

Entities:  

Keywords:  Diabetes; Drug assessment; Hospital use; Observational data; Quasi-experiment

Year:  2022        PMID: 36272025     DOI: 10.1186/s13561-022-00397-5

Source DB:  PubMed          Journal:  Health Econ Rev        ISSN: 2191-1991


  17 in total

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Review 2.  HTA agencies facing model biases: the case of type 2 diabetes.

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Review 3.  Use of incretin-based medications: what do current international recommendations suggest with respect to GLP-1 receptor agonists and DPP-4 inhibitors?

Authors:  Melanie J Davies; Cristina Bianchi; Stefano Del Prato
Journal:  Metabolism       Date:  2020-04-18       Impact factor: 8.694

4.  Factors associated with increased healthcare costs in Medicare Advantage patients with type 2 diabetes enrolled in a large representative health insurance plan in the US.

Authors:  S Lane Slabaugh; Bradley H Curtis; Gosia Clore; Haoda Fu; Dara P Schuster
Journal:  J Med Econ       Date:  2014-11-06       Impact factor: 2.448

5.  New drugs and the growth of health expenditure: evidence from diabetic patients in Taiwan.

Authors:  Ya-Ming Liu; Chee-Ruey Hsieh
Journal:  Health Econ       Date:  2011-03-10       Impact factor: 3.046

Review 6.  Efficacy and safety of incretin therapy in type 2 diabetes: systematic review and meta-analysis.

Authors:  Renee E Amori; Joseph Lau; Anastassios G Pittas
Journal:  JAMA       Date:  2007-07-11       Impact factor: 56.272

Review 7.  Incretin based treatments and mortality in patients with type 2 diabetes: systematic review and meta-analysis.

Authors:  Jiali Liu; Ling Li; Ke Deng; Chang Xu; Jason W Busse; Per Olav Vandvik; Sheyu Li; Gordon H Guyatt; Xin Sun
Journal:  BMJ       Date:  2017-06-08

8.  Hypoglycemia and Dementia Risk in Older Patients with Type 2 Diabetes Mellitus: A Propensity-Score Matched Analysis of a Population-Based Cohort Study.

Authors:  Young Gun Kim; Dong Gyu Park; So Young Moon; Ja Young Jeon; Hae Jin Kim; Dae Jung Kim; Kwan Woo Lee; Seung Jin Han
Journal:  Diabetes Metab J       Date:  2019-10-23       Impact factor: 5.376

9.  Incretin-based therapies for the treatment of type 2 diabetes: evaluation of the risks and benefits.

Authors:  Daniel J Drucker; Steven I Sherman; Fred S Gorelick; Richard M Bergenstal; Robert S Sherwin; John B Buse
Journal:  Diabetes Care       Date:  2010-02       Impact factor: 19.112

10.  Hypoglycemia hospitalization frequency in patients with type 2 diabetes mellitus: a comparison of dipeptidyl peptidase 4 inhibitors and insulin secretagogues using the French health insurance database.

Authors:  Bruno Detournay; Serge Halimi; Julien Robert; Céline Deschaseaux; Sylvie Dejager
Journal:  Vasc Health Risk Manag       Date:  2015-07-17
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