Bhavi Trivedi1, Rohan Desai2, Kunal Mishra3, Lisa Aimee Hechanova2, Mehran Abolbashari4. 1. Department of Internal Medicine, Texas Tech University Health Sciences Center El Paso, 145 W Castellano Dr., Apt #2, El Paso, TX, 79912, USA. btrivedi@ttuhsc.edu. 2. Department of Internal Medicine, Texas Tech University Health Sciences Center El Paso, 145 W Castellano Dr., Apt #2, El Paso, TX, 79912, USA. 3. Department of Cardiovascular Medicine, University of Virginia, Charlottesville, VA, USA. 4. Department of Cardiovascular Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, TX, USA.
Abstract
PURPOSE OF REVIEW: Atherosclerosis is the largest cause of death in the western world with the role of sex yet to be determined. The purpose of this review is to investigate the role sex may play in the development of atherosclerosis. RECENT FINDINGS: Differences in plaque burden play a role in atherosclerotic outcome. Men have a higher prevalence of plaque burden, while women have less plaque rupture, necrotic core, and calcium. Differences in hormones, vascular anatomy, and overall lifestyle all play a role. Estrogen's cardioprotective effect is well known, but there is a lack of consensus on testosterone's role. There are varying rates of atherosclerosis between the sexes. Studies have also shown varying differences in the progression of plaque and the type of plaques between sexes. Further investigations need to be done to solidify the role sex may play as a variable in the development of atherosclerosis and how that may impact future treatment goals.
PURPOSE OF REVIEW: Atherosclerosis is the largest cause of death in the western world with the role of sex yet to be determined. The purpose of this review is to investigate the role sex may play in the development of atherosclerosis. RECENT FINDINGS: Differences in plaque burden play a role in atherosclerotic outcome. Men have a higher prevalence of plaque burden, while women have less plaque rupture, necrotic core, and calcium. Differences in hormones, vascular anatomy, and overall lifestyle all play a role. Estrogen's cardioprotective effect is well known, but there is a lack of consensus on testosterone's role. There are varying rates of atherosclerosis between the sexes. Studies have also shown varying differences in the progression of plaque and the type of plaques between sexes. Further investigations need to be done to solidify the role sex may play as a variable in the development of atherosclerosis and how that may impact future treatment goals.
Authors: Jesse W Williams; Holger Winkels; Christopher P Durant; Konstantin Zaitsev; Yanal Ghosheh; Klaus Ley Journal: Circ Res Date: 2020-04-23 Impact factor: 17.367
Authors: Sameer Arora; George A Stouffer; Anna M Kucharska-Newton; Arman Qamar; Muthiah Vaduganathan; Ambarish Pandey; Deborah Porterfield; Ron Blankstein; Wayne D Rosamond; Deepak L Bhatt; Melissa C Caughey Journal: Circulation Date: 2019-02-19 Impact factor: 29.690