Literature DB >> 36268416

Treatment of generalized pustular psoriasis in pregnancy with systemic corticosteroid: A rare case report.

Ahmed Isse Ali1, Mohamud Mohamed Abdulkadir1, Hassan Ali Mumin1, Abdisalam Ibrahim Aden1, Mohamed Sheikh Hassan2.   

Abstract

Introduction: and importance: Generalized pustular psoriasis of pregnancy (GPPP) is a rare dermatosis that causes maternal and fetal morbidity and mortality. Pustular psoriasis of pregnancy (PPP) is a challenging dermatological Condition, which can have impact on the life pregnant woman's and her unborn child's life. Case presentation: Here we report a 26-year-old woman with a history of persistent plaque psoriasis presented with generalized pustular lesions. Ultrasonography revealed normal fetal development despite high serum ESR and CRP levels. Pustular psoriasis was confirmed by histopathology. The patients were given systemic prednisolone 32 mg once daily, which was raised to 60 mg once daily on the tenth day of treatment to manage fresh outbreaks, and the patient's rash continued to gradually improve. When the lesions faded after 4 weeks of treatment, the dose was reduced to 16 mg/day. At 31 weeks' gestation, the patient was discharged and she was kept on prednisolone at a low dose of 4 mg once daily for the duration of the pregnancy. Clinical discussion: Generalized pustular psoriasis of pregnancy (GPPP), herpetiformis, is a less common form dermatosis that can be fatal for both mother and the fetus. Response to treatment is good when initiated early in the course of the disease. This present case shows young pregnant mother with GPPP successfully treated with systemic corticosteroid.
Conclusion: Contrary to the majority of other common pregnant dermatosis, pustular psoriasis is an uncommon condition that can have harmful effects on the fetus. Our patient's PPP symptoms included systemic ones as well as body and palm involvement. Close monitoring and administration of systemic corticosteroids ensured secure outcomes.
© 2022 The Authors.

Entities:  

Keywords:  Impetigo herpetiformis; Pustular psoriasis of pregnancy; Systemic prednisolone

Year:  2022        PMID: 36268416      PMCID: PMC9577442          DOI: 10.1016/j.amsu.2022.104568

Source DB:  PubMed          Journal:  Ann Med Surg (Lond)        ISSN: 2049-0801


  10 in total

Review 1.  Specific dermatoses of pregnancy and their treatment.

Authors:  Stephanie Lehrhoff; Miriam Keltz Pomeranz
Journal:  Dermatol Ther       Date:  2013 Jul-Aug       Impact factor: 2.851

2.  The SCARE 2020 Guideline: Updating Consensus Surgical CAse REport (SCARE) Guidelines.

Authors:  Riaz A Agha; Thomas Franchi; Catrin Sohrabi; Ginimol Mathew; Ahmed Kerwan
Journal:  Int J Surg       Date:  2020-11-09       Impact factor: 6.071

3.  A case of recurrent impetigo herpetiformis with a positive family history.

Authors:  Z Erbagci; S Erkiliç
Journal:  Int J Clin Pract       Date:  2000-11       Impact factor: 2.503

4.  Personal treatment experience for severe generalized pustular psoriasis of pregnancy: two case reports.

Authors:  Li Luan; Shixin Han; Zhenying Zhang; Xiaoming Liu
Journal:  Dermatol Ther       Date:  2013-12-10       Impact factor: 2.851

5.  Generalized pustular psoriasis of pregnancy successfully treated with cyclosporine.

Authors:  Debeeka Hazarika
Journal:  Indian J Dermatol Venereol Leprol       Date:  2009 Nov-Dec       Impact factor: 2.545

6.  Impetigo herpetiformis unresponsive to therapy in a pregnant adolescent.

Authors:  Ilhan Arslanpence; F Suat Dede; Mehmet Gokcu; Orhan Gelisen
Journal:  J Pediatr Adolesc Gynecol       Date:  2003-06       Impact factor: 1.814

7.  Treatment of Generalized Pustular Psoriasis of Pregnancy With Infliximab.

Authors:  Burcu Beksac; Esra Adisen; Mehmet Ali Gurer
Journal:  Cutis       Date:  2021-03

8.  Cyclosporine in the management of impetigo herpetiformis: a case report and review of the literature.

Authors:  Aikaterini Patsatsi; Theodoros D Theodoridis; Dimitrios Vavilis; Vasilios Tzevelekis; Aikaterini Kyriakou; Dimitrios Kalabalikis; Dimitrios Sotiriadis
Journal:  Case Rep Dermatol       Date:  2013-03-23

9.  A case of impetigo herpetiformis in which termination of pregnancy was required.

Authors:  Xinjing Yao; Xiaoxia Zhang; Min Peng; He Wang; Yizi Meng; Ying Chen
Journal:  J Int Med Res       Date:  2020-07       Impact factor: 1.671

10.  Pustular psoriasis of pregnancy (impetigo herpetiformis)--case report.

Authors:  Rogerio Nabor Kondo; Fernanda Mendes Araújo; Allamanda Moura Pereira; Vivian Cristina Holanda Lopes; Ligia Márcia Mario Martins
Journal:  An Bras Dermatol       Date:  2013 Nov-Dec       Impact factor: 1.896

  10 in total

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