Wenhu Liu1,2,3, Jing Hu1,2,3, Shuai Lu1,2,3, Zhaohui Wang1,2,3. 1. Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. 2. Hubei Key Laboratory of Biological Targeted Therapy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. 3. Hubei Provincial Engineering Research Center of Immunological Diagnosis and Therapy for Cardiovascular Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Abstract
Background and Objective: Myocarditis is a heterogeneous disease that can lead to acute heart failure, dilated cardiomyopathy (DCM), and sudden death. However, the knowledge of the precise molecular mechanisms of myocarditis is fairly limited. In recent years, non-coding RNAs (ncRNAs) have been demonstrated to be involved in many physiological and pathological processes in myocarditis and to have the potential to be used as novel diagnostic and therapeutic strategies for myocarditis. This review summarizes the role of ncRNAs in myocarditis and discusses their potential as noninvasive biomarkers and therapeutic targets for myocarditis. Methods: Literature on ncRNAs and myocarditis published in PubMed was extensively reviewed for analysis and discussion. Key Content and Findings: This review describes the roles of different ncRNAs in myocarditis and summarizes their potential in diagnosing and treating myocarditis. Multiple functions and mechanisms of ncRNAs in myocarditis have been uncovered. Conclusions: Current studies show that ncRNAs are widely involved in the occurrence and development of myocarditis caused by infection, autoimmunity, and the use of immune checkpoint inhibitors (ICIs) through their regulation of cell apoptosis, immune response, viral replication, and other aspects. Small-sample clinical studies have assessed the diagnostic value of ncRNAs. These results provide a new theoretical basis for diagnosing and treating myocarditis. 2022 Annals of Translational Medicine. All rights reserved.
Background and Objective: Myocarditis is a heterogeneous disease that can lead to acute heart failure, dilated cardiomyopathy (DCM), and sudden death. However, the knowledge of the precise molecular mechanisms of myocarditis is fairly limited. In recent years, non-coding RNAs (ncRNAs) have been demonstrated to be involved in many physiological and pathological processes in myocarditis and to have the potential to be used as novel diagnostic and therapeutic strategies for myocarditis. This review summarizes the role of ncRNAs in myocarditis and discusses their potential as noninvasive biomarkers and therapeutic targets for myocarditis. Methods: Literature on ncRNAs and myocarditis published in PubMed was extensively reviewed for analysis and discussion. Key Content and Findings: This review describes the roles of different ncRNAs in myocarditis and summarizes their potential in diagnosing and treating myocarditis. Multiple functions and mechanisms of ncRNAs in myocarditis have been uncovered. Conclusions: Current studies show that ncRNAs are widely involved in the occurrence and development of myocarditis caused by infection, autoimmunity, and the use of immune checkpoint inhibitors (ICIs) through their regulation of cell apoptosis, immune response, viral replication, and other aspects. Small-sample clinical studies have assessed the diagnostic value of ncRNAs. These results provide a new theoretical basis for diagnosing and treating myocarditis. 2022 Annals of Translational Medicine. All rights reserved.
Authors: H Nishimura; T Okazaki; Y Tanaka; K Nakatani; M Hara; A Matsumori; S Sasayama; A Mizoguchi; H Hiai; N Minato; T Honjo Journal: Science Date: 2001-01-12 Impact factor: 47.728
Authors: Sonal Jangalwe; Varun N Kapoor; Jia Xu; Nomeda Girnius; Norman J Kennedy; Yvonne J K Edwards; Raymond M Welsh; Roger J Davis; Michael A Brehm Journal: J Immunol Date: 2019-01-04 Impact factor: 5.422
Authors: Sandra Pinkert; Markian Pryshliak; Kathleen Pappritz; Klaus Knoch; Ahmet Hazini; Babette Dieringer; Katrin Schaar; Fengquan Dong; Luisa Hinze; Jie Lin; Dirk Lassner; Robert Klopfleisch; Michele Solimena; Carsten Tschöpe; Ziya Kaya; Muhammad El-Shafeey; Antje Beling; Jens Kurreck; Sophie Van Linthout; Karin Klingel; Henry Fechner Journal: Cardiovasc Res Date: 2020-08-01 Impact factor: 10.787
Authors: Katrien Van der Borght; Charlotte L Scott; Liesbet Martens; Dorine Sichien; Gert Van Isterdael; Veronika Nindl; Yvan Saeys; Louis Boon; Burkhard Ludewig; Thierry C Gillebert; Bart N Lambrecht Journal: Front Immunol Date: 2018-11-21 Impact factor: 7.561