Literature DB >> 3626770

Ketone formation in the intestinal mucosa of infant rats.

P Hahn, M Taller.   

Abstract

The intestinal mucosa of infant rats was found to produce ketones when incubated in Krebs-Ringer-Bicarbonate solution. No production was found in weaned rats. Ketogenesis could be inhibited by D-carnitine or tetradecylglycidic acid (TDGA) an inhibitor of long-chain acylcarnitine transferase, suggesting that ketone production is due to a large extent to break-down of long-chain fatty acids. It is considered possible that both ketones and glucose (also produced by the infant mucosa) serve as substrates for the muscular part of the intestine.

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Year:  1987        PMID： 3626770     DOI： 10.1016/0024-3205(87)90718-1

Source DB:  PubMed          Journal:  Life Sci        ISSN： 0024-3205            Impact factor:   5.037


  6 in total

Review 1.  Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase: a control enzyme in ketogenesis.

Authors:  F G Hegardt
Journal:  Biochem J       Date:  1999-03-15       Impact factor: 3.857

2.  Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase promoter contains a CREB binding site that regulates cAMP action in Caco-2 cells.

Authors:  A Eggers; C Caudevilla; G Asins; F G Hegardt; D Serra
Journal:  Biochem J       Date:  2000-01-15       Impact factor: 3.857

3.  Gene expression of mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase in a poorly ketogenic mammal: effect of starvation during the neonatal period of the piglet.

Authors:  S H Adams; C S Alho; G Asins; F G Hegardt; P F Marrero
Journal:  Biochem J       Date:  1997-05-15       Impact factor: 3.857

4.  The effect of dexamethasone treatment on the expression of the regulatory genes of ketogenesis in intestine and liver of suckling rats.

Authors:  G Arias; G Asins; F G Hegardt; D Serra
Journal:  Mol Cell Biochem       Date:  1998-01       Impact factor: 3.396

5.  Developmental changes in mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene expression in rat liver, intestine and kidney.

Authors:  S Thumelin; M Forestier; J Girard; J P Pegorier
Journal:  Biochem J       Date:  1993-06-01       Impact factor: 3.857

6.  Developmental changes in carnitine palmitoyltransferases I and II gene expression in intestine and liver of suckling rats.

Authors:  G Asins; D Serra; G Arias; F G Hegardt
Journal:  Biochem J       Date:  1995-03-01       Impact factor: 3.857
  6 in total

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