Literature DB >> 36267610

ALK-Positive Anaplastic Large-Cell Lymphoma in a Patient with Chronic Lymphocytic Leukemia: A Case Report and Literature Review.

Qinchuan Yu1, Zhiqiang Zhao1, He Wang1, Lieyang Wang1.   

Abstract

Chronic lymphocytic leukemia (CLL) can experience histological transformation to a more aggressive lymphoma called "Richter's transformation". This transformation usually leads to diffuse large B cell lymphoma, though cases of T cell lymphoma have been identified. Here we report an extremely rare case of ALK (anaplastic lymphoma kinase) positive anaplastic large cell lymphoma. We performed detailed examination for this patient and reviewed related literatures to understand the transformation. Despite our best effort, this patient passed away shortly. Literature review shows no consensus on treatment and poor prognosis of this condition. We intend to report this case and explore novel treatment possibilities for these patients.
© 2022 Yu et al.

Entities:  

Keywords:  ALCL; CLL; Ig rearrangement; Richter’s transformation

Year:  2022        PMID： 36267610      PMCID： PMC9578959          DOI： 10.2147/OTT.S383779

Source DB:  PubMed          Journal:  Onco Targets Ther        ISSN： 1178-6930            Impact factor:   4.345


  29 in total

1.  Transactivation by temperature-dependent p53 mutants in yeast and human cells.

Authors:  Jana Slovackova; Diana Grochova; Jarmila Navratilova; Jan Smarda; Jana Smardova
Journal:  Cell Cycle       Date:  2010-06-01       Impact factor: 4.534

2.  The genetics of Richter syndrome reveals disease heterogeneity and predicts survival after transformation.

Authors:  Davide Rossi; Valeria Spina; Clara Deambrogi; Silvia Rasi; Luca Laurenti; Kostas Stamatopoulos; Luca Arcaini; Marco Lucioni; Gabrielle B Rocque; Zijun Y Xu-Monette; Carlo Visco; Julie Chang; Ekaterina Chigrinova; Francesco Forconi; Roberto Marasca; Caroline Besson; Theodora Papadaki; Marco Paulli; Luigi M Larocca; Stefano A Pileri; Valter Gattei; Francesco Bertoni; Robin Foà; Ken H Young; Gianluca Gaidano
Journal:  Blood       Date:  2011-01-25       Impact factor: 22.113

3.  Peripheral T-cell lymphomas with cytotoxic phenotype in patients with chronic lymphocytic leukemia/small lymphocytic lymphoma.

Authors:  Daniel F Boyer; Neal I Lindeman; Nancy Lee Harris; Judith Ann Ferry
Journal:  Am J Surg Pathol       Date:  2014-02       Impact factor: 6.394

4.  Gene expression profiling of B cell chronic lymphocytic leukemia reveals a homogeneous phenotype related to memory B cells.

Authors:  U Klein; Y Tu; G A Stolovitzky; M Mattioli; G Cattoretti; H Husson; A Freedman; G Inghirami; L Cro; L Baldini; A Neri; A Califano; R Dalla-Favera
Journal:  J Exp Med       Date:  2001-12-03       Impact factor: 14.307

5.  Clonal relation in a case of CLL, ALCL, and Hodgkin composite lymphoma.

Authors:  Anke van den Berg; Ewerton Maggio; Renata Rust; Klaas Kooistra; Arjan Diepstra; Sibrand Poppema
Journal:  Blood       Date:  2002-08-15       Impact factor: 22.113

6.  Composite ALK-negative anaplastic large cell lymphoma and small lymphocytic lymphoma involving the right inguinal lymph node.

Authors:  Paul Persad; Changlee S Pang
Journal:  Pathol Res Pract       Date:  2013-09-26       Impact factor: 3.250

7.  Transformation of CLL to ALCL: the role of clonality studies in diagnostic molecular haematopathology.

Authors:  Richard Colling; Daniel Royston; Elizabeth Soilleux
Journal:  J Hematop       Date:  2016-08-08       Impact factor: 0.196

8.  Evaluation of 230 patients with relapsed/refractory deletion 17p chronic lymphocytic leukaemia treated with ibrutinib from 3 clinical trials.

Authors:  Jeffrey Jones; Anthony Mato; Steven Coutre; John C Byrd; Richard R Furman; Peter Hillmen; Anders Osterborg; Constantine Tam; Stephan Stilgenbauer; William G Wierda; Nyla A Heerema; Karl Eckert; Fong Clow; Cathy Zhou; Alvina D Chu; Danelle F James; Susan M O'Brien
Journal:  Br J Haematol       Date:  2018-06-05       Impact factor: 6.998

9.  P53-R273H mutation enhances colorectal cancer stemness through regulating specific lncRNAs.

Authors:  Yuechao Zhao; Yiran Li; Jie Sheng; Fan Wu; Kai Li; Rong Huang; Xiaojuan Wang; Tao Jiao; Xin Guan; Yan Lu; Xiao Chen; Zhiwen Luo; Yanchi Zhou; Hanjie Hu; Wenjie Liu; Boyu Du; Shiying Miao; Jianqiang Cai; Linfang Wang; Hong Zhao; Jianming Ying; Xinyu Bi; Wei Song
Journal:  J Exp Clin Cancer Res       Date:  2019-08-28

10.  Oligomerization of Mutant p53 R273H is not Required for Gain-of-Function Chromatin Associated Activities.

Authors:  George K Annor; Nour Elshabassy; Devon Lundine; Don-Gerard Conde; Gu Xiao; Viola Ellison; Jill Bargonetti
Journal:  Front Cell Dev Biol       Date:  2021-11-22
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