Literature DB >> 36267132

Factor XI Activation Inhibitors for Treating Thromboses, Embolism, Hypercoagulability, or Fibrotic Changes.

Ram W Sabnis1.   

Abstract

Provided herein are novel compounds as Factor XIa inhibitors, pharmaceutical compositions, use of such compounds in treating thromboses, embolism, hypercoagulability, or fibrotic changes, and processes for preparing such compounds. Published 2022 by American Chemical Society.

Entities:  

Year:  2022        PMID： 36267132      PMCID： PMC9578030          DOI： 10.1021/acsmedchemlett.2c00392

Source DB:  PubMed          Journal:  ACS Med Chem Lett        ISSN： 1948-5875            Impact factor:   4.632


  6 in total

Review 1.  Translational insight into prothrombotic state and hypercoagulation in nonalcoholic fatty liver disease.

Authors:  Alessandro Ciavarella; Davide Gnocchi; Carlo Custodero; Gennaro Mariano Lenato; Giorgio Fiore; Carlo Sabbà; Antonio Mazzocca
Journal:  Thromb Res       Date:  2020-12-11       Impact factor: 3.944

Review 2.  Factor XI Deficiency.

Authors:  Magdalena Dorota Lewandowska; Jean Marie Connors
Journal:  Hematol Oncol Clin North Am       Date:  2021-09-15       Impact factor: 3.722

Review 3.  The Function of extravascular coagulation factor IX in haemostasis.

Authors:  David M Mann; Katherine A Stafford; Man-Chiu Poon; Davide Matino; Darrel W Stafford
Journal:  Haemophilia       Date:  2021-03-29       Impact factor: 4.287

Review 4.  Anticoagulation in patients with kidney failure on dialysis: factor XI as a therapeutic target.

Authors:  John Eikelboom; Jürgen Floege; Ravi Thadhani; Jeffrey I Weitz; Wolfgang C Winkelmayer
Journal:  Kidney Int       Date:  2021-09-30       Impact factor: 10.612

Review 5.  Dual inhibition of factor XIIa and factor XIa as a therapeutic approach for safe thromboprotection.

Authors:  Stéphanie Demoulin; Edmond Godfroid; Cédric Hermans
Journal:  J Thromb Haemost       Date:  2020-12-10       Impact factor: 5.824

Review 6.  Factor XI Inhibition to Uncouple Thrombosis From Hemostasis: JACC Review Topic of the Week.

Authors:  Charles Hsu; Edward Hutt; Daniel M Bloomfield; David Gailani; Jeffrey I Weitz
Journal:  J Am Coll Cardiol       Date:  2021-08-10       Impact factor: 27.203
  6 in total

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