ALK Inhibitors for Treating Cancer, Blood, and Kidney Diseases.

Cancers that traditionally have been resistant to apoptosis via chemical- or radiation-based therapies may respond when the treatments are combined with ALK-5 inhibition. Disclosures in this Patent Highlight provide inhibitors of activin-receptor-like kinases such as ALK-5, compositions and methods for increasing red blood cell or hemoglobin levels, and activin antagonists to treat, prevent, or reduce the progression rate or severity of kidney disease. Published 2022 by American Chemical Society.