Yu Yu1, Min Gu1, Hao Huang1, Sijing Cheng1, Yu Deng1, Chi Cai1, Xuhua Chen1, Hongxia Niu1, Xiaohui Ning1, Wei Hua2. 1. Cardiac Arrhythmia Center, National Center for Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union MedicalCollege, No. 167 Bei Li Shi Rd, Xicheng District, Beijing, 100037, China. 2. Cardiac Arrhythmia Center, National Center for Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union MedicalCollege, No. 167 Bei Li Shi Rd, Xicheng District, Beijing, 100037, China. drhuaweifw@sina.com.
Abstract
BACKGROUND: The combined association of triglyceride-glucose (TyG) index and different systolic blood pressure (SBP) levels with all-cause and cardiovascular mortality among the general population remains unclear. METHODS: In this study, 6245 individuals were from the National Health and Nutrition Examination Survey (1999-2002). The study endpoints were all-cause and cardiovascular mortality. Multivariate Cox proportional hazards regression models were used to explore the combined association of TyG index and different SBP levels with all-cause and cardiovascular mortality. RESULTS: During a mean follow-up period of 66.8 months, a total of 284 all-cause deaths (331/100000 person-years) and 61 cardiovascular deaths (66/100000 person-years) were recorded. Multivariate Cox regression analysis revealed that the combination of low TyG index and low SBP (< 120 mmHg and < 130 mmHg) was associated with a reduced risk of all-cause and cardiovascular mortality than others. However, survival benefit was not observed in the combined group with the low TyG index and SBP < 140 mmHg. Furthermore, the mortality rate in the combined group of low TyG index and low SBP gradually increased with the elevation of SBP level. CONCLUSION: The combination of low TyG index and low SBP (< 120 mmHg and < 130 mmHg) was associated with a lower risk of all-cause and cardiovascular mortality. However, no survival benefit was observed in the combined group of low TyG index and SBP < 140 mmHg.
BACKGROUND: The combined association of triglyceride-glucose (TyG) index and different systolic blood pressure (SBP) levels with all-cause and cardiovascular mortality among the general population remains unclear. METHODS: In this study, 6245 individuals were from the National Health and Nutrition Examination Survey (1999-2002). The study endpoints were all-cause and cardiovascular mortality. Multivariate Cox proportional hazards regression models were used to explore the combined association of TyG index and different SBP levels with all-cause and cardiovascular mortality. RESULTS: During a mean follow-up period of 66.8 months, a total of 284 all-cause deaths (331/100000 person-years) and 61 cardiovascular deaths (66/100000 person-years) were recorded. Multivariate Cox regression analysis revealed that the combination of low TyG index and low SBP (< 120 mmHg and < 130 mmHg) was associated with a reduced risk of all-cause and cardiovascular mortality than others. However, survival benefit was not observed in the combined group with the low TyG index and SBP < 140 mmHg. Furthermore, the mortality rate in the combined group of low TyG index and low SBP gradually increased with the elevation of SBP level. CONCLUSION: The combination of low TyG index and low SBP (< 120 mmHg and < 130 mmHg) was associated with a lower risk of all-cause and cardiovascular mortality. However, no survival benefit was observed in the combined group of low TyG index and SBP < 140 mmHg.
Authors: Clifford L Johnson; Ryne Paulose-Ram; Cynthia L Ogden; Margaret D Carroll; Deanna Kruszon-Moran; Sylvia M Dohrmann; Lester R Curtin Journal: Vital Health Stat 2 Date: 2013-09
Authors: Marjo Piironen; Olavi Ukkola; Heikki Huikuri; Aki S Havulinna; Heli Koukkunen; Juha Mustonen; Matti Ketonen; Seppo Lehto; Juhani Airaksinen; Y Antero Kesäniemi; Veikko Salomaa Journal: Eur J Prev Cardiol Date: 2016-11-19 Impact factor: 7.804
Authors: Agata Bielecka-Dabrowa; Anna Gluba-Brzózka; Marta Michalska-Kasiczak; Małgorzata Misztal; Jacek Rysz; Maciej Banach Journal: Int J Mol Sci Date: 2015-05-12 Impact factor: 5.923