Literature DB >> 36266653

An NADPH sensor that regulates cell ferroptosis.

Guixing Kuang1, Weidong Wang2, Dan Xiong3, Chong Zeng4.   

Abstract

Ferroptosis is a new form of programmed cell death, which achieved great breakthroughs in cell biology during past decade. However, the regulation of ferroptosis is yet to be identified thoroughly. The latest study published on Nature cell biology by Nguyen and colleagues found a new NADPH sensor, MARCHF6 an E3 ubiquitin ligase, mediates ferroptosis in tumor growth and animal development. This finding provides a novel insight into ubiquitin system and energy metabolism in regulation of ferroptosis, which may open up new avenues for tumor treatment.
© 2022. The Author(s).

Entities:  

Keywords:  Ferroptosis; MARCHF6; NADPH; Ubiquitination

Mesh：

Substances：

Year:  2022        PMID： 36266653      PMCID： PMC9583509          DOI： 10.1186/s12967-022-03658-3

Source DB:  PubMed          Journal:  J Transl Med        ISSN： 1479-5876            Impact factor:   8.440


  10 in total

Review 1.  The E3 ubiquitin ligase MARCHF6 as a metabolic integrator in cholesterol synthesis and beyond.

Authors:  Nicola A Scott; Laura J Sharpe; Andrew J Brown
Journal:  Biochim Biophys Acta Mol Cell Biol Lipids       Date:  2020-10-10       Impact factor: 4.698

2.  Ferroptosis: an iron-dependent form of nonapoptotic cell death.

Authors:  Scott J Dixon; Kathryn M Lemberg; Michael R Lamprecht; Rachid Skouta; Eleina M Zaitsev; Caroline E Gleason; Darpan N Patel; Andras J Bauer; Alexandra M Cantley; Wan Seok Yang; Barclay Morrison; Brent R Stockwell
Journal:  Cell       Date:  2012-05-25       Impact factor: 41.582

3.  PKCβII phosphorylates ACSL4 to amplify lipid peroxidation to induce ferroptosis.

Authors:  Hai-Liang Zhang; Bing-Xin Hu; Zhi-Ling Li; Tian Du; Jia-Lu Shan; Zhi-Peng Ye; Xiao-Dan Peng; Xuan Li; Yun Huang; Xian-Ying Zhu; Yu-Hong Chen; Gong-Kan Feng; Dajun Yang; Rong Deng; Xiao-Feng Zhu
Journal:  Nat Cell Biol       Date:  2022-01-13       Impact factor: 28.824

Review 4.  Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications.

Authors:  Brent R Stockwell
Journal:  Cell       Date:  2022-07-07       Impact factor: 66.850

5.  The MARCHF6 E3 ubiquitin ligase acts as an NADPH sensor for the regulation of ferroptosis.

Authors:  Kha The Nguyen; Sang-Hyeon Mun; Jihye Yang; Jongeun Lee; Ok-Hee Seok; Eunjeong Kim; Dasom Kim; So Young An; Dong-Young Seo; Jeong-Yong Suh; Yoontae Lee; Cheol-Sang Hwang
Journal:  Nat Cell Biol       Date:  2022-08-08       Impact factor: 28.213

6.  SHARPIN promotes cell proliferation of cholangiocarcinoma and inhibits ferroptosis via p53/SLC7A11/GPX4 signaling.

Authors:  Chong Zeng; Jie Lin; Ketao Zhang; Huohui Ou; Ke Shen; Qingbo Liu; Zibo Wei; Xinhuai Dong; Xiaokang Zeng; Liming Zeng; Weidong Wang; Jie Yao
Journal:  Cancer Sci       Date:  2022-08-15       Impact factor: 6.518

7.  The MARCH6-SQLE Axis Controls Endothelial Cholesterol Homeostasis and Angiogenic Sprouting.

Authors:  Josephine Mathilde Elisabeth Tan; Miesje Maxime van der Stoel; Marlene van den Berg; Nienke Marlies van Loon; Martina Moeton; Edwin Scholl; Nicole Neeltje van der Wel; Igor Kovačević; Peter Lodewijk Hordijk; Anke Loregger; Stephan Huveneers; Noam Zelcer
Journal:  Cell Rep       Date:  2020-08-04       Impact factor: 9.423

8.  MESH1 is a cytosolic NADPH phosphatase that regulates ferroptosis.

Authors:  Chien-Kuang Cornelia Ding; Joshua Rose; Tianai Sun; Jianli Wu; Po-Han Chen; Chao-Chieh Lin; Wen-Hsuan Yang; Kai-Yuan Chen; Hana Lee; Emily Xu; Sarah Tian; Jadesola Akinwuntan; Jinshi Zhao; Ziqiang Guan; Pei Zhou; Jen-Tsan Chi
Journal:  Nat Metab       Date:  2020-03-09

9.  MARCH6 promotes Papillary Thyroid Cancer development by destabilizing DHX9.

Authors:  Yang Liu; Siyuan Xu; Ying Huang; Shaoyan Liu; Zhengang Xu; Minghui Wei; Jie Liu
Journal:  Int J Biol Sci       Date:  2021-08-03       Impact factor: 6.580

Review 10.  Ferroptosis in cancer and cancer immunotherapy.

Authors:  Lei Zhao; Xiaoxue Zhou; Feng Xie; Lei Zhang; Haiyan Yan; Jun Huang; Chong Zhang; Fangfang Zhou; Jun Chen; Long Zhang
Journal:  Cancer Commun (Lond)       Date:  2022-02
  10 in total

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