| Literature DB >> 36263097 |
Yibo Ying1,2, Zhiyang Huang1,2, Yurong Tu1,2, Qiuji Wu1,2, Zhaoyu Li3, Yifan Zhang1,2, Huilei Yu1,2, Annian Zeng1,2, Hanzhi Huang1,2, Jiahui Ye1,2, Weiyang Ying1,2,4, Min Chen1,2, Zhiyi Feng1,2, Ziyue Xiang1,2, Qingsong Ye5,6, Sipin Zhu1,2, Zhouguang Wang1,2.
Abstract
Spinal cord injury (SCI) is a serious clinical disease. Due to the deformability and fragility of the spinal cord, overly rigid hydrogels cannot be used to treat SCI. Hence, we used TPA and Laponite to develop a hydrogel with shear-thinning ability. This hydrogel exhibits good deformation, allowing it to match the physical properties of the spinal cord; additionally, this hydrogel scavenges ROS well, allowing it to inhibit the lipid peroxidation caused by ferroptosis. According to the in vivo studies, the TPA@Laponite hydrogel could synergistically inhibit ferroptosis by improving vascular function and regulating iron metabolism. In addition, dental pulp stem cells (DPSCs) were introduced into the TPA@Laponite hydrogel to regulate the ratios of excitatory and inhibitory synapses. It was shown that this combination biomaterial effectively reduced muscle spasms and promoted recovery from SCI.Entities:
Keywords: Dental pulp stem cells; Ferroptosis; ROS-Scavenging; Shear-thinning hydrogel; Synaptic regulation
Year: 2022 PMID： 36263097 PMCID： PMC9556860 DOI： 10.1016/j.bioactmat.2022.09.019
Source DB: PubMed Journal: Bioact Mater ISSN： 2452-199X