Orcan Altan1, Emel Ekşioğlu2, Erhan Arif Öztürk2, Tülin Hakan Demirhan3, Zühre Kaya4, Selin Aytaç Eyüpoğlu5, Vildan Koşan Çulha1, Dilek Gürlek Gökçebay1, Namık Yaşar Özbek1. 1. Pediatric Hematology/Oncology, Ankara Child Health and Diseases Hematology and Oncology Training and Research Hospital, University of Health Sciences, Ziraat Mah. Irfan Bastug Cd. Kurtdereli Sk. No: 10, 06110 Ankara, Turkey. 2. Physical Therapy and Rehabilitation, University of Health Sciences Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey. 3. Pediatric Radiology, Ankara Child Health and Diseases Hematology and Oncology Training and Research Hospital, University of Health Sciences, Ankara, Turkey. 4. Pediatric Hematology, Gazi University Faculty of Medicine, Ankara, Turkey. 5. Pediatric Hematology, Hacettepe University Faculty of Medicine, Ankara, Turkey.
Abstract
Purpose: Hemophilia is a hereditary coagulation disorder characterized by acute hemorrhages into the musculoskeletal system, leading eventually to arthropathy and disability. Chronic inflammation of the synovial membrane arises as a result of frequent joint hemorrhage. Proteolytic enzymes in the blood and cartilage cause deterioration after that, and joint space narrows. Chronic hemophilic arthropathy develops as a result of these unfavorable developments, which occur more quickly, especially in the target joints. Balance is a process that allows us to maintain our orientation in three-dimensional space while also regulating our body posture to avoid falling. After the central nervous system evaluates deep stimuli from sensory, visual, and auditory receptors, movement of the corresponding muscle groups is delivered. Methods: The goal of this study was to investigate how impairment to deep sensory receptors (proprioception) in the arthropathic joint structure affected hemophiliacs' balance. The study comprised 34 patients with hemophilic arthropathy, and 34 age and weight matched healthy volunteers. Results: When balance tests of patients with hemophilic arthropathy were compared to healthy controls, hemophiliacs had a greater risk of falling. As the degree of arthropathy increased, so did the risk of falling and balance test values in individuals with hemophilic arthropathy. Conclusions: Treatment and coagulation factor prophylaxis to prevent the onset of arthropathy will improve patients' quality of life and reduce morbidity associated with frequent falls and bleeding. Supplementary Information: The online version contains supplementary material available at 10.1007/s12288-022-01526-0.
Purpose: Hemophilia is a hereditary coagulation disorder characterized by acute hemorrhages into the musculoskeletal system, leading eventually to arthropathy and disability. Chronic inflammation of the synovial membrane arises as a result of frequent joint hemorrhage. Proteolytic enzymes in the blood and cartilage cause deterioration after that, and joint space narrows. Chronic hemophilic arthropathy develops as a result of these unfavorable developments, which occur more quickly, especially in the target joints. Balance is a process that allows us to maintain our orientation in three-dimensional space while also regulating our body posture to avoid falling. After the central nervous system evaluates deep stimuli from sensory, visual, and auditory receptors, movement of the corresponding muscle groups is delivered. Methods: The goal of this study was to investigate how impairment to deep sensory receptors (proprioception) in the arthropathic joint structure affected hemophiliacs' balance. The study comprised 34 patients with hemophilic arthropathy, and 34 age and weight matched healthy volunteers. Results: When balance tests of patients with hemophilic arthropathy were compared to healthy controls, hemophiliacs had a greater risk of falling. As the degree of arthropathy increased, so did the risk of falling and balance test values in individuals with hemophilic arthropathy. Conclusions: Treatment and coagulation factor prophylaxis to prevent the onset of arthropathy will improve patients' quality of life and reduce morbidity associated with frequent falls and bleeding. Supplementary Information: The online version contains supplementary material available at 10.1007/s12288-022-01526-0.
Authors: F M B De Souza; R P Pereira; N P Minuque; C M Do Carmo; M H M De Mello; P Villaça; C Tanaka Journal: Haemophilia Date: 2012-03-08 Impact factor: 4.287
Authors: Hanna Rehm; Jan Schmolders; Sebastian Koob; Rahel Bornemann; Georg Goldmann; Johannes Oldenburg; Peter Pennekamp; Andreas C Strauss Journal: Hamostaseologie Date: 2016-09-23 Impact factor: 1.778
Authors: Naresh Gupta; Abderrahmane Benbouzid; Meriem Belhani; Mohammed El Andaloussi; Khadija Maani; Yasser Wali; Soraya Benchikh El Fegoun; Hossam Ali Saad; Johnny Mahlangu Journal: TH Open Date: 2019-06-27