Literature DB >> 3625610

Modulation of the natural killer cell activity in pregnant mice alters the spontaneous abortion rate.

A R de Fougerolles, M G Baines.   

Abstract

Effector cells associated with an aborting fetus appear to be both thymus derived (T) and natural killer (NK) cells. In order to test the hypothesis that NK cells are a major effector mediating early spontaneous abortion (less than day 8-10), CBA female mice mated by DBA/2 males were treated with either polyinosinic/cytidylic acid (poly I:C) to boost NK activity, or rabbit anti-asialo GM1 (RaASGM1) to decrease NK activity. The results of the NK assays of the spleens of treated mice confirmed that the reagents had the expected effect on NK activity and an inspection of the uteri indicated a significant increase in aborted embryos after poly I:C and a marked decrease in spontaneous abortions after RaASGM1 treatment. Therefore, spontaneous abortions may be mediated in part by the cytotoxic activity of unregulated NK cells.

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Year:  1987        PMID： 3625610     DOI： 10.1016/0165-0378(87)90018-0

Source DB:  PubMed          Journal:  J Reprod Immunol        ISSN： 0165-0378            Impact factor:   4.054


  14 in total

Review 1.  NKT cells at the maternal-fetal interface.

Authors:  J E Boyson; I Aktan; D A Barkhuff; A Chant
Journal:  Immunol Invest       Date:  2008       Impact factor: 3.657

2.  Cell populations in human early pregnancy decidua: characterization and isolation of large granular lymphocytes by flow cytometry.

Authors:  P M Starkey; I L Sargent; C W Redman
Journal:  Immunology       Date:  1988-09       Impact factor: 7.397

3.  Regulation of pregnancy maintenance and fetal survival in mice by CD27(low) mature NK cells.

Authors:  Khalil Karimi; María Emilia Solano; Ali A Ashkar; Huang Ho; Eva-Maria Steidle; Karen-Anne McVey Neufeld; Kurt Hecher; John Bienenstock; Petra Clara Arck
Journal:  J Mol Med (Berl)       Date:  2012-02-23       Impact factor: 4.599

4.  NKG2D blockade inhibits poly(I:C)-triggered fetal loss in wild type but not in IL-10-/- mice.

Authors:  Jessica E Thaxton; Tania Nevers; Eliana O Lippe; Sandra M Blois; Shigeru Saito; Surendra Sharma
Journal:  J Immunol       Date:  2013-03-01       Impact factor: 5.422

5.  Gestation stage-dependent mechanisms of invariant natural killer T cell-mediated pregnancy loss.

Authors:  Jonathan E Boyson; Nisha Nagarkatti; Leena Nizam; Mark A Exley; Jack L Strominger
Journal:  Proc Natl Acad Sci U S A       Date:  2006-03-14       Impact factor: 11.205

6.  Rat spontaneous foetal resorption: altered α2-macroglobulin levels and uNK cell number.

Authors:  B M Fonseca; M Almada; M A Costa; N A Teixeira; G Correia-da-Silva
Journal:  Histochem Cell Biol       Date:  2014-08-02       Impact factor: 4.304

Review 7.  To drive or be driven: the path of a mouse model of recurrent pregnancy loss.

Authors:  Elizabeth A Bonney; Stephen A Brown
Journal:  Reproduction       Date:  2014-04-08       Impact factor: 3.906

8.  Immunopathology of early pregnancy.

Authors:  G Chaouat; E Menu; B Mognetti; M Moussa; V Cayol; Y Mostefaoui; S Dubanchet; P Khadel; J L Voluménie; C B Rongiéres; G L Delage
Journal:  Infect Dis Obstet Gynecol       Date:  1997

9.  Listeria monocytogenes cytoplasmic entry induces fetal wastage by disrupting maternal Foxp3+ regulatory T cell-sustained fetal tolerance.

Authors:  Jared H Rowe; James M Ertelt; Lijun Xin; Sing Sing Way
Journal:  PLoS Pathog       Date:  2012-08-16       Impact factor: 6.823

10.  Early embryo loss is associated with local production of nitric oxide by decidual mononuclear cells.

Authors:  E K Haddad; A J Duclos; M G Baines
Journal:  J Exp Med       Date:  1995-10-01       Impact factor: 14.307
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