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Literature DB >> 3625208

Ocular motor and manual tracking in Parkinson's disease and the effect of treatment.

Abstract

A quantitative analysis of unpredictable saccadic and smooth pursuit ocular motor and manual tracking was performed in 15 mildly affected, previously untreated subjects suffering from Parkinson's disease and in age-matched normal controls. The patients' ocular saccades were characterised by an increased variability of their latencies and reduced accuracy, with normal velocity profiles apart from saccadic duration. Their smooth pursuit had a decreased velocity gain. Similar abnormalities were found with manual tracking. Clinical improvement with dopaminergic drugs was associated with an improvement of saccadic accuracy and smooth pursuit gain. It is postulated that the ocular motor changes seen in Parkinson's disease are contingent upon functional dopamine levels in the basal ganglia.

Entities: Chemical Disease Species

Mesh：

Substances：
Bromocriptine
Levodopa

Year: 1987 PMID： 3625208 PMCID： PMC1032122 DOI： 10.1136/jnnp.50.7.853

Source DB: PubMed Journal: J Neurol Neurosurg Psychiatry ISSN： 0022-3050 Impact factor: 10.154

26 in total

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Authors: A T Bahill; D Adler; L Stark
Journal: Invest Ophthalmol Date: 1975-06

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Authors: K Flowers
Journal: Neurology Date: 1975-05 Impact factor: 9.910

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Journal: Trans Am Neurol Assoc Date: 1969

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Journal: Mod Treat Date: 1968-03

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Authors: G M Jones; J D DeJong
Journal: Exp Neurol Date: 1971-04 Impact factor: 5.330

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Authors: M M Hoehn; M D Yahr
Journal: Neurology Date: 1967-05 Impact factor: 9.910

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Authors: K A Flowers
Journal: Brain Date: 1976-06 Impact factor: 13.501

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Authors: J D DeJong; G M Jones
Journal: Exp Neurol Date: 1971-07 Impact factor: 5.330

17 in total

Review 1. Ocular motility of aging and dementia.

Authors: Victoria S Pelak
Journal: Curr Neurol Neurosci Rep Date: 2010-11 Impact factor: 5.081

2. Antisaccades and remembered saccades in Parkinson's disease.

Authors: C J Lueck; S Tanyeri; T J Crawford; L Henderson; C Kennard
Journal: J Neurol Neurosurg Psychiatry Date: 1990-04 Impact factor: 10.154

3. Lisuride reduces involuntary periodic leg movements in spinocerebellar ataxia type 2 patients.

Authors: Luis Velázquez-Pérez; Roberto Rodríguez-Labrada; Lázaro Álvarez-González; Raúl Aguilera-Rodríguez; Mario Álvarez Sánchez; Nalia Canales-Ochoa; Lourdes Galicia Polo; Reyes Haro-Valencia; Jacqueline Medrano-Montero; Yaimeé Vázquez-Mojena; Arnoy Peña-Acosta; Annelié Estupiñán-Rodríguez; Noemí Rodríguez Pupo
Journal: Cerebellum Date: 2012-12 Impact factor: 3.847

Ocular motor and manual tracking in Parkinson's disease and the effect of treatment.

1. Most naturally occurring human saccades have magnitudes of 15 degrees or less.

2. Ballistic and corrective movements on an aiming task. Intention tremor and parkinsonian movement disorders compared.

3. Ocular dyskinesias in patients with Parkinson's disease treated with levodopa.

4. Oculomotor function in patients with Parkinson's disease.

5. Changes in saccadic eye movements of patients with Parkinson's disease before and after L-dopa.

6. Critical analysis of the disability in Parkinson's disease.

7. Dynamic characteristics of saccadic eye movements in Parkinson's disease.

8. Parkinsonism: onset, progression and mortality.

9. Visual "closed-loop" and "open-loop" characteristics of voluntary movement in patients with Parkinsonism and intention tremor.

10. Akinesia, hypokinesia, and bradykinesia in the oculomotor system of patients with Parkinson's disease.

Review 1. Ocular motility of aging and dementia.

2. Antisaccades and remembered saccades in Parkinson's disease.

3. Lisuride reduces involuntary periodic leg movements in spinocerebellar ataxia type 2 patients.

4. Progressive bradykinesia and hypokinesia of ocular pursuit in Parkinson's disease.

5. Impaired oculomotor function in a community-based patient population with newly diagnosed idiopathic parkinsonism.

6. [Abnormal eye movements in patients with idiopathic rapid eye movement sleep behavior disorder].

7. The effect of L-Dopa administration on pursuit ocular movements in suspected Parkinson's disease.

Review 8. Pharmacological treatment effects on eye movement control.

9. Saccadic latency distributions in Parkinson's disease and the effects of L-dopa.

10. Freezing of saccades in dopa-responsive parkinsonian syndrome.