Literature DB >> 3625197

Growth-inhibiting effect of crude pineal extracts on human melanoma cells in vitro is different from that of known synthetic pineal substances.

H Bartsch, C Bartsch, H P Noteborn, B Flehmig, I Ebels, C A Salemink.   

Abstract

The effect was studied of a number of synthetic indoleamines, pteridines, beta-carbolines, of AVT and of crude extracts from rat and ovine pineal glands on human melanoma cells in vitro. The identified pineal substances as well as some of their analogues showed an inhibitory effect only at non-physiologically high concentrations. However, crude pineal extracts were more active than the synthetic pineal substances tested. They contain a compound which may have a tumor-inhibiting potency comparable to that of methotrexate but a different mechanism of action.

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Year:  1987        PMID： 3625197     DOI： 10.1007/BF01244350

Source DB:  PubMed          Journal:  J Neural Transm            Impact factor:   3.575


  19 in total

1.  Separation of pineal extracts by gelfiltration. VI. Isolation and identification from sheep pineals of biopterin; comparison of the isolated compound with some synthetic pteridines and the biological activity in in vitro and in vivo bioassays.

Authors:  M L van der Have-Kirchberg; A de Morée; J F van Laar; G J Gerwig; C Versluis; I Ebels
Journal:  J Neural Transm       Date:  1977       Impact factor: 3.575

2.  Butterfly wing antineoplastic agents.

Authors:  G R Pettit; L E Houghton; N H Rogers; R M Coomes; D F Berger; P R Reucroft; J F Day; J L Hartwell; H B Wood
Journal:  Experientia       Date:  1972-04-15

3.  The effect of ovine pineal compounds prepared under red or green light on the activity of male rat anterior pituitaries in vitro.

Authors:  A Slama-Scemama; H P Noteborn; A de Morée; G M de Korte-Kool; P Leblanc; F Gogan; A L'Héritier; I Ebels
Journal:  J Neural Transm       Date:  1985       Impact factor: 3.575

4.  [Demonstration in the hypothalamus and partial purification of a substance which inhibits in vitro cell multiplication].

Authors:  M Jutisz; M Bindoni; S Ribot GStanzani
Journal:  C R Acad Hebd Seances Acad Sci D       Date:  1974-11-04

5.  6-methoxy-1,2,3,4-tetrahydro-beta-carboline in pineal gland of chicken and cock.

Authors:  I Kari
Journal:  FEBS Lett       Date:  1981-05-18       Impact factor: 4.124

6.  Effects of some low molecular weight sheep pineal fractions and melatonin on different tumors in rats and mice.

Authors:  V Lapin; I Ebels
Journal:  Oncology       Date:  1976       Impact factor: 2.935

7.  Study of the anti-tumor effect of polypeptide pineal extract.

Authors:  V M Dilman; V N Anisimov; M N Ostroumova; V G Morosov; V K Khavinson; M A Azarova
Journal:  Oncology       Date:  1979       Impact factor: 2.935

8.  Characterization and partial purification of a substance in the pineal gland which inhibits cell multiplication in vitro.

Authors:  M Bindoni; M Jutisz; G Ribot
Journal:  Biochim Biophys Acta       Date:  1976-07-21

9.  Effect of melatonin on experimental tumors under different photoperiods and times of administration.

Authors:  H Bartsch; C Bartsch
Journal:  J Neural Transm       Date:  1981       Impact factor: 3.575

Review 10.  Beta-carbolines, psychoactive compounds in the mammalian body. Part I: Occurrence, origin and metabolism.

Authors:  M M Airaksinen; I Kari
Journal:  Med Biol       Date:  1981-02
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  1 in total

1.  Partial purification of (a) low molecular weight ovine pineal compound(s) with an inhibiting effect on the growth of human melanoma cells in vitro.

Authors:  H P Noteborn; H Bartsch; C Bartsch; D R Mans; J J Weusten; B Flehmig; I Ebels; C A Salemink
Journal:  J Neural Transm       Date:  1988       Impact factor: 3.575
  1 in total

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