Literature DB >> 36251785

Empagliflozin Inhibits Cardiac Late Sodium Current by Ca/Calmodulin-Dependent Kinase II.

Julian Mustroph1, Maria J Baier1, Steffen Pabel1, Thea Stehle1, Maximilian Trum1, Zdenek Provaznik2, Peter J Mohler3, Hassan Musa3, Thomas J Hund3, Samuel Sossalla1, Lars S Maier1, Stefan Wagner1.   

Abstract

Entities:  

Keywords:  CaMKII; SGLT2 inhibitors; heart failure

Mesh：

Substances：

Year:  2022        PMID： 36251785      PMCID： PMC9586469          DOI： 10.1161/CIRCULATIONAHA.122.057364

Source DB:  PubMed          Journal:  Circulation        ISSN： 0009-7322            Impact factor:   39.918


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  5 in total

1.  Reactive oxygen species-activated Ca/calmodulin kinase IIδ is required for late I(Na) augmentation leading to cellular Na and Ca overload.

Authors:  Stefan Wagner; Hanna M Ruff; Sarah L Weber; Sarah Bellmann; Thomas Sowa; Timo Schulte; Mark E Anderson; Eleonora Grandi; Donald M Bers; Johannes Backs; Luiz Belardinelli; Lars S Maier
Journal:  Circ Res       Date:  2011-01-20       Impact factor: 17.367

2.  Ca2+/calmodulin-dependent protein kinase II regulates cardiac Na+ channels.

Authors:  Stefan Wagner; Nataliya Dybkova; Eva C L Rasenack; Claudius Jacobshagen; Larissa Fabritz; Paulus Kirchhof; Sebastian K G Maier; Tong Zhang; Gerd Hasenfuss; Joan Heller Brown; Donald M Bers; Lars S Maier
Journal:  J Clin Invest       Date:  2006-11-22       Impact factor: 14.808

3.  Cardiac Late Sodium Channel Current Is a Molecular Target for the Sodium/Glucose Cotransporter 2 Inhibitor Empagliflozin.

Authors:  Koenraad Philippaert; Subha Kalyaanamoorthy; Mohammad Fatehi; Wentong Long; Shubham Soni; Nikole J Byrne; Amy Barr; Jyoti Singh; Jordan Wong; Taylor Palechuk; Chloe Schneider; Ahmed M Darwesh; Zaid H Maayah; John M Seubert; Khaled Barakat; Jason R B Dyck; Peter E Light
Journal:  Circulation       Date:  2021-04-09       Impact factor: 29.690

Review 4.  Mechanisms of Cardiovascular Benefits of Sodium Glucose Co-Transporter 2 (SGLT2) Inhibitors: A State-of-the-Art Review.

Authors:  Gary D Lopaschuk; Subodh Verma
Journal:  JACC Basic Transl Sci       Date:  2020-06-22

5.  Empagliflozin reduces Ca/calmodulin-dependent kinase II activity in isolated ventricular cardiomyocytes.

Authors:  Julian Mustroph; Olivia Wagemann; Charlotte M Lücht; Maximilian Trum; Karin P Hammer; Can Martin Sag; Simon Lebek; Daniel Tarnowski; Jörg Reinders; Filippo Perbellini; Cesare Terracciano; Christof Schmid; Simon Schopka; Michael Hilker; York Zausig; Steffen Pabel; Samuel T Sossalla; Frank Schweda; Lars S Maier; Stefan Wagner
Journal:  ESC Heart Fail       Date:  2018-08
  5 in total

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