Literature DB >> 36250036

Costs by Site of Service for Commercially-Insured Patients with Metastatic Pancreatic Cancer Receiving Guideline-Recommended Chemotherapy: Comparing Community Oncology and Hospital Outpatient Settings.

Samantha Tomicki1, Gabriela Dieguez1, David DeStephano1, Melody Chang2, Paul Cockrum3.   

Abstract

Purpose: Compare total cost of care (TCOC) for commercially-insured patients with metastatic pancreatic cancer receiving FDA-approved/NCCN Category 1 preferred regimens in community oncology or hospital outpatient settings. Patients and
Methods: We used the 2016-2019 MarketScan® and Milliman Consolidated Health Cost Guidelines Sources Database (CHSD) administrative claims data to compare utilization of healthcare services and expenditures for commercially-insured patients receiving chemotherapy in community oncology or hospital outpatient settings. We identified patients with metastatic pancreatic cancer using ICD-10 diagnosis codes in 2016-2019 MarketScan® and Milliman Consolidated Health Cost Guidelines Sources Database files. Patients were assigned to cohorts based on where they received the plurality of chemotherapy services: community oncology or hospital outpatient settings. Total cost of care (TCOC) and healthcare resource utilization metrics were calculated per line of therapy (LOT) for patients receiving similar chemotherapy regimens in each cohort, and differences between cohorts were evaluated using t-testing and chi-squared statistical methods.
Results: Although cohorts had similar demographics, chemotherapy regimen use, and length of therapy, the mean TCOC among all patients receiving chemotherapy in hospital outpatient settings was 41% higher compared to community oncology settings. Median TCOC was 35% higher in hospital outpatient settings than in community oncology settings. Mean admissions and readmissions per beneficiary were 7% and 16% higher, respectively, for thse treated in hospital outpatient versus community oncology settings. We observed no differences in the use of emergency department or hospice care between the cohorts.
Conclusion: Our study indicates that patients receiving chemotherapy at community oncology centers are associated with better or equivalent outcomes and lower costs than patients receiving the same regimen in a hospital outpatient setting.
© 2022 Tomicki et al.

Entities:  

Keywords:  340B; chemotherapy; claims analysis; reimbursement

Year:  2022        PMID: 36250036      PMCID: PMC9563737          DOI: 10.2147/CEOR.S373316

Source DB:  PubMed          Journal:  Clinicoecon Outcomes Res        ISSN: 1178-6981


  13 in total

1.  Consequences of the 340B Drug Pricing Program.

Authors:  Sunita Desai; J Michael McWilliams
Journal:  N Engl J Med       Date:  2018-01-24       Impact factor: 91.245

2.  Spending by Commercial Insurers on Chemotherapy Based on Site of Care, 2004-2014.

Authors:  Aaron N Winn; Nancy L Keating; Justin G Trogdon; Ethan M Basch; Stacie B Dusetzina
Journal:  JAMA Oncol       Date:  2018-04-01       Impact factor: 31.777

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Journal:  Therap Adv Gastroenterol       Date:  2017-06-27       Impact factor: 4.409

4.  Cost differential by site of service for cancer patients receiving chemotherapy.

Authors:  Jad Hayes; Russell J Hoverman; Matthew E Brow; Dana C Dilbeck; Diana K Verrilli; Jody Garey; Janet L Espirito; Jorge Cardona; Roy Beveridge
Journal:  Am J Manag Care       Date:  2015-03-01       Impact factor: 2.229

Review 5.  Charlson Comorbidity Index: A Critical Review of Clinimetric Properties.

Authors:  Mary E Charlson; Danilo Carrozzino; Jenny Guidi; Chiara Patierno
Journal:  Psychother Psychosom       Date:  2022-01-06       Impact factor: 17.659

6.  National estimates of price variation by site of care.

Authors:  Aparna Higgins; German Veselovskiy; Jill Schinkel
Journal:  Am J Manag Care       Date:  2016-03-01       Impact factor: 2.229

7.  Comparative Safety and Efficacy of Therapeutic Options in Resectable and Advanced/Metastatic Pancreatic Cancer: A Systematic Review and Indirect Comparison.

Authors:  Aditi Kharat; Madeline Brendle; Anindit Chhibber; Nathorn Chaiyakunapruk; Joseph Biskupiak
Journal:  Oncol Res Treat       Date:  2021-07-27       Impact factor: 2.825

8.  Charlson Comorbidity Index: ICD-9 Update and ICD-10 Translation.

Authors:  William P Glasheen; Tristan Cordier; Rajiv Gumpina; Gil Haugh; Jared Davis; Andrew Renda
Journal:  Am Health Drug Benefits       Date:  2019 Jun-Jul

9.  The harmonic mean p-value for combining dependent tests.

Authors:  Daniel J Wilson
Journal:  Proc Natl Acad Sci U S A       Date:  2019-01-04       Impact factor: 11.205

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