Yan Zhou1, Yanhong Deng2, Yanjie You2, Xue Li2, Di Zhang3, Hailong Qi4, Ruichun Shi5, Li Yao2, Yuanyuan Tang2, Xiaofei Li2, Linke Ma2, Yanlin Li2, Jun Liu2, Yaning Feng2, Xianmei Chen2, Qian Hao2, Xuemei Li2, Yuzhen Li2, Min Niu2, Hengjun Gao6,7,8, Feihu Bai9,10, Shengjuan Hu2. 1. Ningxia Medical University Yinchuan, China. 2. People's Hospital of Ningxia Hui Autonomous Region (Ningxia Medical University Affiliated People's Hospital of Autonomous Region) Yinchuan, China. 3. Department of Gastroenterology, People's Hospital of Jingyuan Guyuan, China. 4. Department of Gastroenterology, Second People's Hospital of Shizuishan Shizuishan, China. 5. Department of Gastroenterology, People's Hospital of Wuzhong Wuzhong, China. 6. Tongji Hospital, School of Medicine, Tongji University Shanghai, China. 7. Institute of Digestive Disease, School of Medicine, Tongji University Shanghai, China. 8. China Center for Helicobacter Pylori Molecular Medicine Shanghai, China. 9. Department of Gastroenterology, The Second Affiliated Hospital of Hainan Medical College Haikou, China. 10. The Gastroenterology Clinical Medical Center of Hainan Province Haikou, China.
Abstract
OBJECTIVES: Helicobacter pylori (H. pylori) infection causes a variety of intragastric and extragastric diseases. Despite its decreasing global prevalence, it remains a major public health problem in many developing countries. This study aimed to understand the prevalence of H. pylori infection and its risk factors in five cities of the Ningxia Hui Autonomous Region, an area with high incidence of gastric cancer. METHODS: Cross-sectional studies were conducted in Ningxia from 2017 and 2022, to detect the prevalence of H. pylori using the 14C urea breath test. All participants completed a questionnaire that included demographics, personal habits, household economic characteristics, and previous health status. Multiple logistic regression analyses were used to identify independent factors for H. pylori infection. RESULTS: Our findings demonstrated that the prevalence of H. pylori infection in Ningxia decreased significantly from 60.3% in 2017 to 43.6% in 2022, with an increase in public awareness rate from 35.9% in 2017 to 68.5% in 2022. The lowest infection rate was found in Zhongwei and highest in Guyuan. The prevalence of H. pylori infection was higher among Hui ethnicity, farmers, individuals living in rural areas, individuals with lower income, low education, and those who consumed less fruit. Gallbladder, respiratory, cardiovascular and autoimmune diseases were not associated with H. pylori infection. CONCLUSIONS: The prevalence of H. pylori in Ningxia decreased in the past five years. Ethnicity, location, occupation, income, education, and consumption of fruits were independent risk factors for H. pylori infection in Ningxia. It was not associated with extra-gastric disease. AJTR
OBJECTIVES: Helicobacter pylori (H. pylori) infection causes a variety of intragastric and extragastric diseases. Despite its decreasing global prevalence, it remains a major public health problem in many developing countries. This study aimed to understand the prevalence of H. pylori infection and its risk factors in five cities of the Ningxia Hui Autonomous Region, an area with high incidence of gastric cancer. METHODS: Cross-sectional studies were conducted in Ningxia from 2017 and 2022, to detect the prevalence of H. pylori using the 14C urea breath test. All participants completed a questionnaire that included demographics, personal habits, household economic characteristics, and previous health status. Multiple logistic regression analyses were used to identify independent factors for H. pylori infection. RESULTS: Our findings demonstrated that the prevalence of H. pylori infection in Ningxia decreased significantly from 60.3% in 2017 to 43.6% in 2022, with an increase in public awareness rate from 35.9% in 2017 to 68.5% in 2022. The lowest infection rate was found in Zhongwei and highest in Guyuan. The prevalence of H. pylori infection was higher among Hui ethnicity, farmers, individuals living in rural areas, individuals with lower income, low education, and those who consumed less fruit. Gallbladder, respiratory, cardiovascular and autoimmune diseases were not associated with H. pylori infection. CONCLUSIONS: The prevalence of H. pylori in Ningxia decreased in the past five years. Ethnicity, location, occupation, income, education, and consumption of fruits were independent risk factors for H. pylori infection in Ningxia. It was not associated with extra-gastric disease. AJTR
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