Literature DB >> 3624300

Efficacy of beta-diketonato complexes of titanium, zirconium, and hafnium against chemically induced autochthonous colonic tumors in rats.

H Bischoff, M R Berger, B K Keppler, D Schmähl.   

Abstract

Bis-beta-diketonato complexes of titanium, zirconium, and hafnium were tested against autochthonous colorectal tumors in rats. The model was found to reflect the clinical situation most closely. Of the compounds tested, budotitane was the most effective in terms of decrease in tumor weight and number and in increasing the lifespan of the treated animals. The therapeutic efficiency was superior to that of 5-fluorouracil, which so far has been the drug with the best activity in patients suffering from colon cancer.

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Year:  1987        PMID： 3624300     DOI： 10.1007/BF00390038

Source DB:  PubMed          Journal:  J Cancer Res Clin Oncol        ISSN： 0171-5216            Impact factor:   4.553


  7 in total

1.  Antitumor activity of cis-dihalogenobis(1-phenyl-1,3-butanedionato)titanium (IV) compounds. A new class of antineoplastic agents.

Authors:  H J Keller; B Keppler; D Schmähl
Journal:  J Cancer Res Clin Oncol       Date:  1983       Impact factor: 4.553

2.  Preclinical evaluation of dichlorobis(1-phenylbutane-1,3-dionato)titanium (IV) and budotitane. Two representatives of the new class of antitumor-active bis-beta-diketonato metal complexes.

Authors:  B K Keppler; D Schmähl
Journal:  Arzneimittelforschung       Date:  1986-12

3.  Autochthonous, acetoxymethylmethylnitrosamine-induced colorectal cancer in rats: a useful tool in selecting new active antineoplastic compounds?

Authors:  M R Berger; H Bischoff; F T Garzon; D Schmähl
Journal:  Hepatogastroenterology       Date:  1986-10

4.  Chemotherapeutic studies on N-nitrosoacetoxymethyl-methylamine-and 1,2-dimethylhydrazine-induced colonic tumors in rats: monotherapy with 5-fluorouracil, ftorafur, CGP 6809, and CGP 15'720A.

Authors:  I Wagner; M Habs; D Schmähl; H Amberger; U Bachmann
Journal:  J Cancer Res Clin Oncol       Date:  1982       Impact factor: 4.553

5.  Antitumor activity of 1.3-diketonato zirconium (IV) and hafnium (IV) complexes.

Authors:  B K Keppler; K Michels
Journal:  Arzneimittelforschung       Date:  1985

6.  Antitumor activity of phenyl substituted dihalogenobis (1-phenyl-1,3-butanedionato)titanium (IV) compounds.

Authors:  B K Keppler; A Diez; V Seifried
Journal:  Arzneimittelforschung       Date:  1985

7.  Antitumor activity of cis-dihalogenobis(1-phenyl-1,3-butanedionato) titanium(IV) compounds against Walker 256 carcinosarcoma. A new class of antineoplastic agents.

Authors:  H J Keller; B Keppler; D Schmähl
Journal:  Arzneimittelforschung       Date:  1982
  7 in total
  6 in total

1.  In vitro anticancer activity of cis-diammineplatinum(II) complexes with β-diketonate leaving group ligands.

Authors:  Justin J Wilson; Stephen J Lippard
Journal:  J Med Chem       Date:  2012-05-18       Impact factor: 7.446

2.  Activity of two platinum-linked phosphonic acids against autochthonous rat colorectal cancer as well as in two human colon-cancer cell lines.

Authors:  A Galeano; M R Berger; B K Keppler
Journal:  Cancer Chemother Pharmacol       Date:  1992       Impact factor: 3.333

3.  Clinical phase I and pharmacokinetic trial of the new titanium complex budotitane.

Authors:  T Schilling; K B Keppler; M E Heim; G Niebch; H Dietzfelbinger; J Rastetter; A R Hanauske
Journal:  Invest New Drugs       Date:  1996       Impact factor: 3.850

Review 4.  Complexes of metals other than platinum as antitumour agents.

Authors:  P Köpf-Maier
Journal:  Eur J Clin Pharmacol       Date:  1994       Impact factor: 2.953

5.  In vitro evaluation of platinum, titanium and ruthenium metal complexes in cisplatin-sensitive and -resistant rat ovarian tumors.

Authors:  S Frühauf; W J Zeller
Journal:  Cancer Chemother Pharmacol       Date:  1991       Impact factor: 3.333

6.  Structurally Characterized BODIPY-Appended Oxidovanadium(IV) β-Diketonates for Mitochondria-Targeted Photocytotoxicity.

Authors:  Utso Bhattacharyya; Brijesh K Verma; Rupak Saha; Nandini Mukherjee; Md Kausar Raza; Somarupa Sahoo; Paturu Kondaiah; Akhil R Chakravarty
Journal:  ACS Omega       Date:  2020-02-24
  6 in total

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