Lu Huang1, Xiao Shuai2, Tingting Zhang3, Pu Kuang2, Dan Zhang4, Tao Chen1, Haoming Tian1, Bing Xiang2, Yan Ren5. 1. Department of Endocrinology and Metabolism, Adrenal Center, West China Hospital of Sichuan University, Chengdu, Sichuan, China. 2. Department of Hematology, West China Hospital of Sichuan University, Chengdu, Sichuan, China. 3. Department of Health Management Center, West China Hospital of Sichuan University, Chengdu, Sichuan, China. 4. Department of Endocrinology and Metabolism, Hospital of Chengdu Office of People's Government of Tibetan Autonomous Region, Chengdu, Sichuan, China. 5. Department of Endocrinology and Metabolism, Adrenal Center, West China Hospital of Sichuan University, Chengdu, Sichuan, China. renyan@scu.edu.cn.
Abstract
PURPOSE: Primary adrenal lymphoma (PAL) is an extremely rare entity, there were few cases have been reported. We report a 52-year-old female with unilateral PAL. METHODS: Case report. RESULTS: A rapid biopsy resulted in the diagnosis of diffuse large B-cell lymphoma after excluding pheochromocytoma. R-CHOP combined with CNS prophylaxis and autologous stem cell transplant (ASCT) has produced an excellent outcome. CONCLUSIONS: Primary adrenal lymphoma (PAL) is a sporadic and highly invasive malignant disease. Symptoms are atypical, making it difficult to obtain an accurate early diagnosis. Adrenal incidentaloma is usually the first clinical manifestation. Some patients may have fever, night sweats, weight loss, and lumbar and abdominal pain. Adrenal insufficiency (AI) may occur in a subset of patients. The identification of other adrenal malignancies, especially catecholamine-secreting tumors, is particularly important for early diagnosis.
PURPOSE: Primary adrenal lymphoma (PAL) is an extremely rare entity, there were few cases have been reported. We report a 52-year-old female with unilateral PAL. METHODS: Case report. RESULTS: A rapid biopsy resulted in the diagnosis of diffuse large B-cell lymphoma after excluding pheochromocytoma. R-CHOP combined with CNS prophylaxis and autologous stem cell transplant (ASCT) has produced an excellent outcome. CONCLUSIONS: Primary adrenal lymphoma (PAL) is a sporadic and highly invasive malignant disease. Symptoms are atypical, making it difficult to obtain an accurate early diagnosis. Adrenal incidentaloma is usually the first clinical manifestation. Some patients may have fever, night sweats, weight loss, and lumbar and abdominal pain. Adrenal insufficiency (AI) may occur in a subset of patients. The identification of other adrenal malignancies, especially catecholamine-secreting tumors, is particularly important for early diagnosis.
Authors: C Laurent; O Casasnovas; L Martin; A Chauchet; H Ghesquieres; G Aussedat; L M Fornecker; S Bologna; S Borot; K Laurent; B Bouillet; B Verges; J-M Petit Journal: QJM Date: 2017-02-01