Literature DB >> 3624113

Suppression of penicillin-induced bacteriolysis of staphylococci by some anticoagulants.

J Wecke, E Kwa, M Lahav, I Ginsburg, P Giesbrecht.   

Abstract

Heparinoids and related negatively-charged substances caused suppression of the penicillin-induced bacteriolysis of staphylococci and a higher viability rate. Furthermore, the penicillin-induced release of cell wall material was reduced by these substances. The main reason for this suppression of bacteriolysis was an inhibition of the activity of cell wall autolytic enzymes while the penicillin-specific perturbations of wall morphogenesis were not affected.

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Year:  1987        PMID: 3624113     DOI: 10.1093/jac/20.1.47

Source DB:  PubMed          Journal:  J Antimicrob Chemother        ISSN: 0305-7453            Impact factor:   5.790


  2 in total

Review 1.  Staphylococcal cell wall: morphogenesis and fatal variations in the presence of penicillin.

Authors:  P Giesbrecht; T Kersten; H Maidhof; J Wecke
Journal:  Microbiol Mol Biol Rev       Date:  1998-12       Impact factor: 11.056

2.  Multi-drug strategies are necessary to inhibit the synergistic mechanism causing tissue damage and organ failure in post infectious sequelae.

Authors:  I Ginsburg
Journal:  Inflammopharmacology       Date:  1999       Impact factor: 5.093

  2 in total

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