Literature DB >> 3623846

Immunocytochemical localization of ornithine aminotransferase in rat ocular tissues.

O Takahashi, S Ishiguro, T Mito, S Hayasaka, T Shiono, K Mizuno, T Ohura, K Tada.   

Abstract

Gyrate atrophy of the choroid and retina is a rare inherited form of chorioretinal degeneration due to a deficiency of ornithine aminotransferase (OAT). We localized the enzyme in rat ocular tissues using immunocytochemical procedures. Immunoreactivity was observed in the epithelia of ciliary body, iris, and lens. Retinal pigment epithelium and Müller cells were immunoreactive in the retina. A little immunoreactive product was found in the choroid. Our findings suggested that OAT plays an important role in ornithine metabolism in these ocular tissues.

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Year:  1987        PMID： 3623846

Source DB:  PubMed          Journal:  Invest Ophthalmol Vis Sci        ISSN： 0146-0404            Impact factor:   4.799


  3 in total

1.  Müller cell alterations from long-term ambient fluorescent light exposure in monkeys: light and electron microscopic, fluorescein and lipofuscin study.

Authors:  D K Berler
Journal:  Trans Am Ophthalmol Soc       Date:  1989

2.  Colocalization in pericentral hepatocytes in adult mice and similarity in developmental expression pattern of ornithine aminotransferase and glutamine synthetase mRNA.

Authors:  F C Kuo; W L Hwu; D Valle; J E Darnell
Journal:  Proc Natl Acad Sci U S A       Date:  1991-11-01       Impact factor: 11.205

3.  A mouse model of gyrate atrophy of the choroid and retina. Early retinal pigment epithelium damage and progressive retinal degeneration.

Authors:  T Wang; A H Milam; G Steel; D Valle
Journal:  J Clin Invest       Date:  1996-06-15       Impact factor: 14.808
  3 in total

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