Wentao Xu1, Yueyuan You1, Tianqi Yu1, Jing Li1. 1. Research Center of Clinical Epidemiology and Evidence-Based Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.
Abstract
OBJECTIVE: Observational studies have linked lifestyle, diet, obesity, and biochemical measures with infertility. Whether this association is causal is unclear. We sought to identify the causal relationship between modifiable risk factors with infertility. METHODS: Using single-nucleotide polymorphisms (SNPs) as a genetic instrument variable, we carried out a two-sample Mendelian randomization (MR) analysis to estimate the causal effects for 22 modifiable risk factors on female infertility (6481 cases; 75,450 participants) and male infertility (680 cases; 73,479 participants). RESULTS: The results of the study showed that BMI (OR: 1.24, 95% CI (1.09, 1.40)), body fat percentage (OR: 1.73, 95% CI (1.13, 2.64)), and alcohol consumption (OR: 6.57,95% CI (1.2, 36.14)) are associated with a higher risk of male infertility, and total fatty acids (OR: 1.16, 95% CI (1.03, 1.30), omega-6 fatty acids (OR: 1.14, 95% CI (1.00, 1.27)), and monounsaturated fatty acids (OR: 1.14, 95% CI (1.03, 1.28) are associated with a higher risk of infertility in women. We observed that higher education (OR: 0.77, 95% CI (0.64, 0.92)) was a protective factor for female infertility. CONCLUSIONS: BMI, body fat percentage, and alcohol consumption are risk factors for male infertility; total fatty acids, omega-6 fatty acids, and monounsaturated fatty acids are risk factors for female infertility, and education is a protective factor for female infertility.
OBJECTIVE: Observational studies have linked lifestyle, diet, obesity, and biochemical measures with infertility. Whether this association is causal is unclear. We sought to identify the causal relationship between modifiable risk factors with infertility. METHODS: Using single-nucleotide polymorphisms (SNPs) as a genetic instrument variable, we carried out a two-sample Mendelian randomization (MR) analysis to estimate the causal effects for 22 modifiable risk factors on female infertility (6481 cases; 75,450 participants) and male infertility (680 cases; 73,479 participants). RESULTS: The results of the study showed that BMI (OR: 1.24, 95% CI (1.09, 1.40)), body fat percentage (OR: 1.73, 95% CI (1.13, 2.64)), and alcohol consumption (OR: 6.57,95% CI (1.2, 36.14)) are associated with a higher risk of male infertility, and total fatty acids (OR: 1.16, 95% CI (1.03, 1.30), omega-6 fatty acids (OR: 1.14, 95% CI (1.00, 1.27)), and monounsaturated fatty acids (OR: 1.14, 95% CI (1.03, 1.28) are associated with a higher risk of infertility in women. We observed that higher education (OR: 0.77, 95% CI (0.64, 0.92)) was a protective factor for female infertility. CONCLUSIONS: BMI, body fat percentage, and alcohol consumption are risk factors for male infertility; total fatty acids, omega-6 fatty acids, and monounsaturated fatty acids are risk factors for female infertility, and education is a protective factor for female infertility.
Authors: James R Staley; James Blackshaw; Mihir A Kamat; Steve Ellis; Praveen Surendran; Benjamin B Sun; Dirk S Paul; Daniel Freitag; Stephen Burgess; John Danesh; Robin Young; Adam S Butterworth Journal: Bioinformatics Date: 2016-06-17 Impact factor: 6.937
Authors: Mihir A Kamat; James A Blackshaw; Robin Young; Praveen Surendran; Stephen Burgess; John Danesh; Adam S Butterworth; James R Staley Journal: Bioinformatics Date: 2019-11-01 Impact factor: 6.937