Literature DB >> 3623010

Effects of anti-GRP gamma-globulin on gastrin release and gastric secretion in the rat: evidence for the physiologic role of endogenous GRP in the regulation of gastric function.

A Takagi, M Moriga, H Uchino, M Aono.   

Abstract

To assess the effects of endogenous GRP on vagal gastrin release and acid secretion, anti-GRP gamma-globulin was infused in anesthetized rats to bind endogenously released GRP. Anti-GRP gamma-globulin blocked the gastrin-releasing effects caused by 4 micrograms/kg/hr of exogenous GRP infusion and suppressed gastrin release by electrical vagal stimulation. In spite of this suppression, anti-GRP gamma-globulin did not alter basal or vagal-stimulated acid secretion.

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Year:  1987        PMID： 3623010     DOI： 10.1007/bf02774253

Source DB:  PubMed          Journal:  Gastroenterol Jpn        ISSN： 0435-1339


  15 in total

1.  Continuous recording of acid gastric secretion in the rat.

Authors:  M N GHOSH; H O SCHILD
Journal:  Br J Pharmacol Chemother       Date:  1958-03

2.  Peptide-containing nerve fibers in the stomach wall of rat and mouse.

Authors:  E Ekblad; M Ekelund; H Graffner; R Håkanson; F Sundler
Journal:  Gastroenterology       Date:  1985-07       Impact factor: 22.682

3.  Relation of gastric acid and pepsin secretion to serum gastrin levels in dogs given bombesin and gastrin-17.

Authors:  B I Hirschowitz; E Molina
Journal:  Am J Physiol       Date:  1983-05

4.  Is gastrin releasing peptide mammalian bombesin?

Authors:  M Brown; W Märki; J Rivier
Journal:  Life Sci       Date:  1980-07-14       Impact factor: 5.037

5.  Paradoxical effects of gastrin releasing peptide on gastrin release and gastric secretion in the rat.

Authors:  A Takagi; M Moriga; H Narusawa; H Uchino; M Aono
Journal:  Gastroenterol Jpn       Date:  1986-12

6.  Effect of GRP on beta-adrenergic-stimulated gastrin and somatostatin release in the isolated rat stomach.

Authors:  G M Short; G M Reel; J W Doyle; M M Wolfe
Journal:  Am J Physiol       Date:  1985-08

7.  Stimulation of gastrin and somatostatin secretion from the isolated rat stomach by bombesin.

Authors:  J W DuVal; B Saffouri; G C Weir; J H Walsh; A Arimura; G M Makhlouf
Journal:  Am J Physiol       Date:  1981-09

8.  Gastrin-releasing peptide: pharmacokinetics and effects on gastro-entero-pancreatic hormones and gastric secretion in normal men.

Authors:  U Knigge; J J Holst; S Knuhtsen; B Petersen; T Krarup; J Holst-Pedersen; P M Christiansen
Journal:  J Clin Endocrinol Metab       Date:  1984-08       Impact factor: 5.958

9.  STUDIES ON GASTRIN.

Authors:  S K LAI
Journal:  Gut       Date:  1964-08       Impact factor: 23.059

10.  Vagal regulation of GRP, gastric somatostatin, and gastrin secretion in vitro.

Authors:  S Nishi; Y Seino; J Takemura; H Ishida; M Seno; T Chiba; C Yanaihara; N Yanaihara; H Imura
Journal:  Am J Physiol       Date:  1985-04
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