Literature DB >> 36229606

Metabolic communication in the tumour-immune microenvironment.

Kung-Chi Kao1,2, Stefania Vilbois1,2, Chin-Hsien Tsai3, Ping-Chih Ho4,5.   

Abstract

The metabolically hostile tumour microenvironment imposes barriers to tumour-infiltrating immune cells and impedes durable clinical remission following immunotherapy. Metabolic communication between cancer cells and their neighbouring immune cells could determine the amplitude and type of immune responses, highlighting a potential involvement of metabolic crosstalk in immune surveillance and escape. In this Review, we explore tumour-immune metabolic crosstalk and discuss potential nutrient-limiting strategies that favour anti-tumour immune responses.
© 2022. Springer Nature Limited.

Entities:  

Year:  2022        PMID： 36229606     DOI： 10.1038/s41556-022-01002-x

Source DB:  PubMed          Journal:  Nat Cell Biol        ISSN： 1465-7392            Impact factor:   28.213


  138 in total

1.  Posttranscriptional control of T cell effector function by aerobic glycolysis.

Authors:  Chih-Hao Chang; Jonathan D Curtis; Leonard B Maggi; Brandon Faubert; Alejandro V Villarino; David O'Sullivan; Stanley Ching-Cheng Huang; Gerritje J W van der Windt; Julianna Blagih; Jing Qiu; Jason D Weber; Edward J Pearce; Russell G Jones; Erika L Pearce
Journal:  Cell       Date:  2013-06-06       Impact factor: 41.582

Review 2.  Navigating metabolic pathways to enhance antitumour immunity and immunotherapy.

Authors:  Xiaoyun Li; Mathias Wenes; Pedro Romero; Stanley Ching-Cheng Huang; Sarah-Maria Fendt; Ping-Chih Ho
Journal:  Nat Rev Clin Oncol       Date:  2019-07       Impact factor: 66.675

3.  The glucose transporter Glut1 is selectively essential for CD4 T cell activation and effector function.

Authors:  Andrew N Macintyre; Valerie A Gerriets; Amanda G Nichols; Ryan D Michalek; Michael C Rudolph; Divino Deoliveira; Steven M Anderson; E Dale Abel; Benny J Chen; Laura P Hale; Jeffrey C Rathmell
Journal:  Cell Metab       Date:  2014-06-12       Impact factor: 27.287

4.  Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression.

Authors:  Chih-Hao Chang; Jing Qiu; David O'Sullivan; Michael D Buck; Takuro Noguchi; Jonathan D Curtis; Qiongyu Chen; Mariel Gindin; Matthew M Gubin; Gerritje J W van der Windt; Elena Tonc; Robert D Schreiber; Edward J Pearce; Erika L Pearce
Journal:  Cell       Date:  2015-08-27       Impact factor: 41.582

Review 5.  Understanding the Warburg effect: the metabolic requirements of cell proliferation.

Authors:  Matthew G Vander Heiden; Lewis C Cantley; Craig B Thompson
Journal:  Science       Date:  2009-05-22       Impact factor: 47.728

6.  Disturbed mitochondrial dynamics in CD8+ TILs reinforce T cell exhaustion.

Authors:  Yi-Ru Yu; Hana Imrichova; Haiping Wang; Tung Chao; Zhengtao Xiao; Min Gao; Marcela Rincon-Restrepo; Fabien Franco; Raphael Genolet; Wan-Chen Cheng; Camilla Jandus; George Coukos; Yi-Fan Jiang; Jason W Locasale; Alfred Zippelius; Pu-Ste Liu; Li Tang; Christoph Bock; Nicola Vannini; Ping-Chih Ho
Journal:  Nat Immunol       Date:  2020-10-05       Impact factor: 25.606

7.  Cell-programmed nutrient partitioning in the tumour microenvironment.

Authors:  Bradley I Reinfeld; Matthew Z Madden; Melissa M Wolf; Anna Chytil; Jackie E Bader; Andrew R Patterson; Ayaka Sugiura; Allison S Cohen; Ahmed Ali; Brian T Do; Alexander Muir; Caroline A Lewis; Rachel A Hongo; Kirsten L Young; Rachel E Brown; Vera M Todd; Tessa Huffstater; Abin Abraham; Richard T O'Neil; Matthew H Wilson; Fuxue Xin; M Noor Tantawy; W David Merryman; Rachelle W Johnson; Christopher S Williams; Emily F Mason; Frank M Mason; Katherine E Beckermann; Matthew G Vander Heiden; H Charles Manning; Jeffrey C Rathmell; W Kimryn Rathmell
Journal:  Nature       Date:  2021-04-07       Impact factor: 49.962

Review 8.  Metabolic barriers to cancer immunotherapy.

Authors:  Kristin DePeaux; Greg M Delgoffe
Journal:  Nat Rev Immunol       Date:  2021-04-29       Impact factor: 53.106

9.  Quantification of microenvironmental metabolites in murine cancers reveals determinants of tumor nutrient availability.

Authors:  Mark R Sullivan; Laura V Danai; Caroline A Lewis; Sze Ham Chan; Dan Y Gui; Tenzin Kunchok; Emily A Dennstedt; Matthew G Vander Heiden; Alexander Muir
Journal:  Elife       Date:  2019-04-16       Impact factor: 8.140

10.  Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses.

Authors:  Ping-Chih Ho; Jessica Dauz Bihuniak; Andrew N Macintyre; Matthew Staron; Xiaojing Liu; Robert Amezquita; Yao-Chen Tsui; Guoliang Cui; Goran Micevic; Jose C Perales; Steven H Kleinstein; E Dale Abel; Karl L Insogna; Stefan Feske; Jason W Locasale; Marcus W Bosenberg; Jeffrey C Rathmell; Susan M Kaech
Journal:  Cell       Date:  2015-08-27       Impact factor: 41.582
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