Application of phenacyl bromide analogs as a versatile organic intermediate for the synthesis of heterocyclic compounds via multicomponent reactions.

Due to the increased interest in heterocyclic compounds over the past decade, many pharmaceutical and organic chemists have explored the synthesis of various materials. Among the many organic compounds that can be synthesized in a wide range of chemical reactions, phenacyl bromide has proven to be a good, inexpensive, versatile, and efficient intermediate. This review presents an overview of the significant applications of phenacyl bromide, focusing on its role in recent synthetic advances and its utility in multicomponent reactions and literature reports for 2017 to the end of 2021.