Takayuki Shibutani1,2, Masahisa Onoguchi3,4, Takayuki Kanno2,5,6, Hiroshi Wakabayashi7, Tomo Hiromasa7, Seigo Kinuya7. 1. Department of Quantum Medical Technology, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, 5-11-80, Kodatsuno, Kanazawa, Japan. 2. Department of Quantum Medical Technology, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan. 3. Department of Quantum Medical Technology, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, 5-11-80, Kodatsuno, Kanazawa, Japan. onoguchi@staff.kanazawa-u.ac.jp. 4. Department of Quantum Medical Technology, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan. onoguchi@staff.kanazawa-u.ac.jp. 5. Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan. 6. Department of Radiological Technology, Nagoya University Hospital, Nagoya, Japan. 7. Department of Nuclear Medicine, Kanazawa University Hospital, Kanazawa, Japan.
Abstract
BACKGROUND: Myocardial phantom studies are widely used as a tool to accurately assess the physical phenomenon of dual-isotope simultaneous acquisition (DISA) in the small-animal fields. However, the previous phantom did not reproduce the structures of rats or mice. The aim of this study was to develop a novel myocardial phantom simulating the structure of a small animal that can be evaluated using the image quality of DISA. METHODS: A novel small-animal myocardial phantom that simulated a rat was constructed by the myocardium, liver, lung, spine, and torso. Normal and inferior wall defect myocardial phantoms were filled with 99mTc or 18F solution to simulate single-isotope acquisition (SIA) and DISA. Phantom and small-animal images with no scatter correction (nonSC) and scatter correction (SC) were created. RESULTS: The 99mTc DISA with SC showed a low %CV compared to that with nonSC. Although the 99mTc DISA with nonSC had lower cavity contrast than that of 99mTc SIA with nonSC, the cavity contrast of SC had similar values between SIA and DISA. The minimum %uptake of 99mTc SIA with nonSC was a lower value compared to that of 99mTc DISA with nonSC. The 99mTc DISA was equivalent to the minimum %uptake of 99mTc SIA by SC. CONCLUSION: We have developed a novel myocardial phantom for the rat model to evaluate the image quality for reproducing the physical phenomenon associated with radiation attenuation and scattering. Furthermore, we could demonstrate the usefulness of the novel small-animal myocardial phantom by image quality evaluation of DISA with 99mTc and 18F compared to SIA.
BACKGROUND: Myocardial phantom studies are widely used as a tool to accurately assess the physical phenomenon of dual-isotope simultaneous acquisition (DISA) in the small-animal fields. However, the previous phantom did not reproduce the structures of rats or mice. The aim of this study was to develop a novel myocardial phantom simulating the structure of a small animal that can be evaluated using the image quality of DISA. METHODS: A novel small-animal myocardial phantom that simulated a rat was constructed by the myocardium, liver, lung, spine, and torso. Normal and inferior wall defect myocardial phantoms were filled with 99mTc or 18F solution to simulate single-isotope acquisition (SIA) and DISA. Phantom and small-animal images with no scatter correction (nonSC) and scatter correction (SC) were created. RESULTS: The 99mTc DISA with SC showed a low %CV compared to that with nonSC. Although the 99mTc DISA with nonSC had lower cavity contrast than that of 99mTc SIA with nonSC, the cavity contrast of SC had similar values between SIA and DISA. The minimum %uptake of 99mTc SIA with nonSC was a lower value compared to that of 99mTc DISA with nonSC. The 99mTc DISA was equivalent to the minimum %uptake of 99mTc SIA by SC. CONCLUSION: We have developed a novel myocardial phantom for the rat model to evaluate the image quality for reproducing the physical phenomenon associated with radiation attenuation and scattering. Furthermore, we could demonstrate the usefulness of the novel small-animal myocardial phantom by image quality evaluation of DISA with 99mTc and 18F compared to SIA.