Literature DB >> 36227346

[Salivary gland tumors-an overview : Advances in molecular characterization: Part I].

Niels J Rupp1,2, Sandra N Freiberger3.   

Abstract

In recent years, the characterization of salivary gland tumors has undergone a major transformation. Morphologically defined entities could to a large extent also be characterized molecularly with an often distinct genotype. The first part of this article reviews the advances in the molecular characteristics of mucoepidermoid carcinoma, adenoid cystic carcinoma, acinic cell carcinoma, secretory carcinoma, intraductal carcinoma, and hyalinizing clear cell carcinoma. The molecular genotype can be particularly useful in classifying unusual morphologic variants. Recurrent NTRK or RET gene fusions can be used not only as a diagnostic tool but also for potential targeted therapy.
© 2022. The Author(s).

Entities:  

Keywords:  Classification; Gene fusion; Morphological and microscopic findings; Mutation; Salivary gland neoplasms

Mesh：

Year:  2022        PMID： 36227346      PMCID： PMC9584877          DOI： 10.1007/s00292-022-01123-y

Source DB:  PubMed          Journal:  Pathologie (Heidelb)        ISSN： 2731-7188


  30 in total

1.  The HTN3-MSANTD3 Fusion Gene Defines a Subset of Acinic Cell Carcinoma of the Salivary Gland.

Authors:  Simon Andreasen; Sushama Varma; Nicholas Barasch; Lester D R Thompson; Markku Miettinen; Lisa Rooper; Edward B Stelow; Tina K Agander; Raja R Seethala; Simion I Chiosea; Preben Homøe; Irene Wessel; Stine R Larsen; Daiva Erentaite; Justin A Bishop; Benedicte P Ulhøi; Katalin Kiss; Linea C Melchior; Jonathan R Pollack; Robert B West
Journal:  Am J Surg Pathol       Date:  2019-04       Impact factor: 6.394

2.  Clinicopathological significance of EGFR pathway gene mutations and CRTC1/3-MAML2 fusions in salivary gland mucoepidermoid carcinoma.

Authors:  Maki Morita; Takayuki Murase; Yoshihide Okumura; Kaori Ueda; Yuma Sakamoto; Ayako Masaki; Daisuke Kawakita; Yuichiro Tada; Ken-Ichi Nibu; Yasuyuki Shibuya; Hiroshi Inagaki
Journal:  Histopathology       Date:  2020-05-15       Impact factor: 5.087

3.  Nuclear NR4A3 Immunostaining Is a Specific and Sensitive Novel Marker for Acinic Cell Carcinoma of the Salivary Glands.

Authors:  Florian Haller; Alena Skálová; Stephan Ihrler; Bruno Märkl; Matthias Bieg; Evgeny A Moskalev; Ramona Erber; Susanne Blank; Christa Winkelmann; Simone Hebele; Martina Baněčková; Stefan Wiemann; Sarina Müller; Johannes Zenk; Roland Eils; Heinrich Iro; Arndt Hartmann; Abbas Agaimy
Journal:  Am J Surg Pathol       Date:  2019-09       Impact factor: 6.394

Review 4.  What the EWSR1-ATF1 fusion has taught us about hyalinizing clear cell carcinoma.

Authors:  Jeff Tanguay; Ilan Weinreb
Journal:  Head Neck Pathol       Date:  2013-03-05

Review 5.  An update on grading of salivary gland carcinomas.

Authors:  Raja R Seethala
Journal:  Head Neck Pathol       Date:  2009-02-25

6.  Expanding the Molecular Spectrum of Secretory Carcinoma of Salivary Glands With a Novel VIM-RET Fusion.

Authors:  Alena Skálová; Martina Banečkova; Lester D R Thompson; Nikola Ptáková; Todd M Stevens; Luka Brcic; Martin Hyrcza; Michael Michal; Roderick H W Simpson; Thalita Santana; Michal Michal; Tomas Vaněček; Ilmo Leivo
Journal:  Am J Surg Pathol       Date:  2020-10       Impact factor: 6.394

7.  NR4A3 Immunostain Is a Highly Sensitive and Specific Marker for Acinic Cell Carcinoma in Cytologic and Surgical Specimens.

Authors:  Kartik Viswanathan; Shaham Beg; Bing He; Taotao Zhang; Richard Cantley; Daniel J Lubin; Qiuying Shi; Zahra Maleki; Saeed Asiry; Rema Rao; Nora Katabi; Masato Nakaguro; William C Faquin; Peter M Sadow; Momin T Siddiqui; Theresa Scognamiglio
Journal:  Am J Clin Pathol       Date:  2022-01-06       Impact factor: 5.400

8.  Activating NOTCH1 Mutations Define a Distinct Subgroup of Patients With Adenoid Cystic Carcinoma Who Have Poor Prognosis, Propensity to Bone and Liver Metastasis, and Potential Responsiveness to Notch1 Inhibitors.

Authors:  Renata Ferrarotto; Yoshitsugu Mitani; Lixia Diao; Irene Guijarro; Jing Wang; Patrick Zweidler-McKay; Diana Bell; William N William; Bonnie S Glisson; Michael J Wick; Ann M Kapoun; Amita Patnaik; Gail Eckhardt; Pamela Munster; Leonardo Faoro; Jakob Dupont; J Jack Lee; Andrew Futreal; Adel K El-Naggar; John V Heymach
Journal:  J Clin Oncol       Date:  2016-11-21       Impact factor: 44.544

9.  MUC4 is a valuable marker for distinguishing secretory carcinoma of the salivary glands from its mimics.

Authors:  Cecilia Taverna; Martina Baněčková; Monica Lorenzon; Annarita Palomba; Alessandro Franchi; Alena Skalova; Abbas Agaimy
Journal:  Histopathology       Date:  2020-11-09       Impact factor: 5.087

10.  Enhancer hijacking activates oncogenic transcription factor NR4A3 in acinic cell carcinomas of the salivary glands.

Authors:  Florian Haller; Matthias Bieg; Rainer Will; Cindy Körner; Dieter Weichenhan; Alexander Bott; Naveed Ishaque; Pavlo Lutsik; Evgeny A Moskalev; Sarina K Mueller; Marion Bähr; Angelika Woerner; Birgit Kaiser; Claudia Scherl; Marlen Haderlein; Kortine Kleinheinz; Rainer Fietkau; Heinrich Iro; Roland Eils; Arndt Hartmann; Christoph Plass; Stefan Wiemann; Abbas Agaimy
Journal:  Nat Commun       Date:  2019-01-21       Impact factor: 14.919
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