Literature DB >> 3622732

The synthesis of stereoselectively labelled porphobilinogen and its incorporation into protoporphyrin-IX.

A H Jackson, W Lertwanawatana, G Procter, S G Smith.   

Abstract

11-(R)-2H porphobilinogen, stereospecifically labelled with deuterium in the aminomethylene group has been incorporated into protoporphyrin-IX by haemolysates of chicken erythrocytes. High field NMR spectroscopy confirms that the overall biochemical process is stereospecific, deuterium being retained at the alpha-, gamma- and delta-meso positions and lost from the beta-meso position.

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Year:  1987        PMID: 3622732     DOI: 10.1007/bf01951654

Source DB:  PubMed          Journal:  Experientia        ISSN: 0014-4754


  2 in total

1.  Biosynthesis of porphyrins and related macrocycles. Part V. Structural integrity of the type III porphyrinogen macrocycle in an active biological system; studies on the aromatisation of protoporphyrinogen-IX.

Authors:  A R Battersby; E McDonald; J R Redfern; J Staunton; R H Wightman
Journal:  J Chem Soc Perkin 1       Date:  1976

2.  Conversion of coproporphyrinogen 3 to protoporphyrin IX.

Authors:  A H Jackson; D E Games; P Couch; J R Jackson; R B Belcher; S G Smith
Journal:  Enzyme       Date:  1974
  2 in total
  1 in total

Review 1.  Porphobilinogen deaminase and uroporphyrinogen III synthase: structure, molecular biology, and mechanism.

Authors:  P M Shoolingin-Jordan
Journal:  J Bioenerg Biomembr       Date:  1995-04       Impact factor: 2.945

  1 in total

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